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路易体痴呆的影响、诊断标准及治疗综述

A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment.

作者信息

Capouch Samuel D, Farlow Martin R, Brosch Jared R

机构信息

Department of Neurology, Indiana University School of Medicine, 355 W 16th St #4700, Indianapolis, IN, 46202, USA.

出版信息

Neurol Ther. 2018 Dec;7(2):249-263. doi: 10.1007/s40120-018-0104-1. Epub 2018 Jul 9.

DOI:10.1007/s40120-018-0104-1
PMID:29987534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6283803/
Abstract

Dementia with Lewy bodies is one of the most common causes of dementia. It is not as common as Alzheimer's disease; the general public's awareness of the disease is poor in comparison. Its effects on caregivers and patients alike are not well known to the general population. There are currently no FDA-approved medications specifically for the treatment of DLB. Many of the medications that are approved for Alzheimer's disease are widely used in the treatment of DLB with varying degrees of success. Treatment of DLB is life long and requires a dedicated team of physicians and caregivers to minimize the degree of morbidity and mortality experienced by the patients suffering from the disease as it progresses.

摘要

路易体痴呆是痴呆最常见的病因之一。它不像阿尔茨海默病那么常见;相比之下,公众对这种疾病的认知度较低。普通大众对其给护理人员和患者带来的影响了解甚少。目前尚无美国食品药品监督管理局(FDA)批准的专门用于治疗路易体痴呆的药物。许多已被批准用于治疗阿尔茨海默病的药物也被广泛用于治疗路易体痴呆,且取得了不同程度的成功。路易体痴呆的治疗是终身的,需要一支专业的医生和护理人员团队,以尽量降低随着疾病进展患者所经历的发病程度和死亡率。

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A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment.路易体痴呆的影响、诊断标准及治疗综述
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Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?路易体痴呆和帕金森病痴呆是同一种疾病吗?
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Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders.脑脊液α-突触核蛋白无法区分不同的痴呆症。
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Caregiving for People with Lewy Body Dementia During A Pandemic: A Qualitative Analysis of Caregivers who Completed Resilience Coaching.疫情期间对路易体痴呆患者的照护:对完成复原力辅导的照护者的定性分析
medRxiv. 2025 Jul 18:2025.07.17.25331719. doi: 10.1101/2025.07.17.25331719.
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Brief Report: A Qualitative Analysis on the Earlier Impacts of COVID-19 on Caregivers of People With Lewy Body Dementia.简报:对新冠疫情早期对路易体痴呆症患者照料者影响的定性分析
Sage Open Aging. 2025 Jul 20;11:30495334251356938. doi: 10.1177/30495334251356938. eCollection 2025 Jan-Dec.
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The 100 most influential papers on Lewy body dementias: a bibliometric analysis.关于路易体痴呆症的100篇最具影响力的论文:文献计量分析
Ann Med Surg (Lond). 2025 Jan 31;87(2):684-695. doi: 10.1097/MS9.0000000000002909. eCollection 2025 Feb.
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Cholesterol-mediated Lysosomal Dysfunction in Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue.胆固醇介导的星形胶质细胞溶酶体功能障碍促进人脑组织中的α-突触核蛋白病理改变。
bioRxiv. 2025 Feb 14:2025.02.09.637107. doi: 10.1101/2025.02.09.637107.
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The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegenerative Diseases.寻找针对特定和混合病理神经退行性疾病的通用治疗方法。
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Do we need to assess autonomic dysfunction in Lewy body dementia?我们是否需要评估路易体痴呆中的自主神经功能障碍?
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本文引用的文献

1
Editorial Regarding: Practical Treatment of Lewy Body Disease in the Clinic: Patient and Physician Perspectives.关于《临床路易体病的实际治疗:患者与医生视角》的社论
Neurol Ther. 2018 Jun;7(1):1-3. doi: 10.1007/s40120-018-0100-5. Epub 2018 Apr 27.
2
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.路易体痴呆的遗传结构研究:一项两阶段全基因组关联研究。
Lancet Neurol. 2018 Jan;17(1):64-74. doi: 10.1016/S1474-4422(17)30400-3. Epub 2017 Dec 16.
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Non-pharmacological interventions for Lewy body dementia: a systematic review.非药物干预路易体痴呆症的系统评价。
Psychol Med. 2018 Aug;48(11):1749-1758. doi: 10.1017/S0033291717003257. Epub 2017 Nov 16.
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Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.路易体痴呆的诊断与管理:DLB联盟第四次共识报告
Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7.
5
Efficacy, Safety, and Tolerability of Armodafinil Therapy for Hypersomnia Associated with Dementia with Lewy Bodies: A Pilot Study.阿得拉非尼治疗路易体痴呆相关睡眠过多的疗效、安全性和耐受性:一项初步研究。
Dement Geriatr Cogn Disord. 2017;43(5-6):269-280. doi: 10.1159/000471507. Epub 2017 Apr 28.
6
Detecting the Cognitive Prodrome of Dementia with Lewy Bodies: A Prospective Study of REM Sleep Behavior Disorder.使用 REM 睡眠行为障碍前瞻性研究来发现路易体痴呆的认知前驱期
Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw014.
7
Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.人神经前体细胞移植可改善路易体痴呆转基因模型的行为并减少 α-突触核蛋白。
Stem Cells Transl Med. 2017 Jun;6(6):1477-1490. doi: 10.1002/sctm.16-0362. Epub 2017 Feb 22.
8
Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial.血浆多奈哌齐浓度升高可改善路易体痴呆患者的认知功能:一项3期随机对照试验中的探索性药代动力学/药效学分析。
J Neurol Sci. 2016 Jul 15;366:184-190. doi: 10.1016/j.jns.2016.05.001. Epub 2016 May 4.
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Economic Impact of Dementia by Disease Severity: Exploring the Relationship between Stage of Dementia and Cost of Care in Taiwan.按疾病严重程度划分的痴呆症经济影响:探究台湾痴呆症阶段与护理成本之间的关系。
PLoS One. 2016 Feb 9;11(2):e0148779. doi: 10.1371/journal.pone.0148779. eCollection 2016.
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Role of Donepezil in the Management of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia with Lewy Bodies.多奈哌齐在阿尔茨海默病和路易体痴呆神经精神症状管理中的作用。
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