Department of General Surgery, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, People's Republic of China.
Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200232, People's Republic of China.
Surg Endosc. 2018 Dec;32(12):4990-4998. doi: 10.1007/s00464-018-6263-4. Epub 2018 Jul 9.
Although laparoscopic common bile duct exploration (LCBDE) has shown many obvious advantages compared with open surgery in the treatment of common bile duct (CBD) stones, it remains unclear regarding risk factors of conversion from LCBDE to open surgery and whether conversion will counteract the advantages of LCBDE. The purpose of this study was to explore risk factors and consequences of conversion from LCBDE to open surgery.
A retrospective study was conducted, using a database of 644 patients with LCBDE between 2011 and 2017. Risk factors for conversion to open surgery were determined based on univariable and multivariable analysis. The consequences of conversion to open surgery in LCBDE were analyzed.
Conversion was required in 27 (4.2%) of 644 patients undergoing LCBDE. Independent risk factors for conversion were as follows: the max diameter of stones in CBD (odds ratio (OR) 2.234, 95%CI 1.031-4.842; p = 0.042), edema of CBD (OR 12.530, 95%CI 4.633-33.887; p < 0.001), and multiple stones in CBD (OR 3.438, 95%CI: 1.133-10.428; p = 0.029). These risk factors and their combined were good predictors for conversion in LCBDE. More blood loss, longer operative time, longer postoperative hospital stay, and higher incision infection were identified in patients with conversion than those without conversion. However, no significant differences were observed regarding mortality, readmission within 30 days, reoperation, bile leakage, and intra-abdominal fluid collection.
Conversion to open surgery in LCBDE was associated with acute edematous CBD with large and multiple stones. Conversion can offset the advantages of LCBDE.
虽然腹腔镜胆总管探查术(LCBDE)在治疗胆总管(CBD)结石方面与开放手术相比具有许多明显的优势,但LCBDE 转为开放手术的风险因素以及是否会抵消 LCBDE 的优势仍不清楚。本研究旨在探讨 LCBDE 转为开放手术的风险因素及后果。
回顾性分析 2011 年至 2017 年 644 例行 LCBDE 患者的数据库。根据单因素和多因素分析确定转为开放手术的危险因素。分析 LCBDE 转为开放手术的后果。
644 例行 LCBDE 的患者中有 27 例(4.2%)需要转为开放手术。转为开放手术的独立危险因素如下:CBD 内结石最大直径(比值比(OR)2.234,95%置信区间(CI)1.031-4.842;p=0.042)、CBD 水肿(OR 12.530,95%CI 4.633-33.887;p<0.001)和 CBD 多发结石(OR 3.438,95%CI:1.133-10.428;p=0.029)。这些危险因素及其组合是 LCBDE 中转行的良好预测指标。与未转换的患者相比,转换患者的出血量更多、手术时间更长、术后住院时间更长、切口感染率更高。但死亡率、30 天内再入院、再次手术、胆漏和腹腔积液等方面无显著差异。
LCBDE 转为开放手术与急性水肿性 CBD 伴大结石和多发结石有关。转换可能会抵消 LCBDE 的优势。