Department of Dermatology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, 2065, Australia.
Sydney Medical School Northern, The University of Sydney, St Leonards, NSW, Australia.
Am J Clin Dermatol. 2018 Oct;19(5):695-706. doi: 10.1007/s40257-018-0364-7.
Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, it is associated with a 2-6% lifetime risk of malignant squamous neoplasia of the vulva. Lichen sclerosus has been considered a difficult to manage condition; however, both serious complications can potentially be prevented with early intervention with topical corticosteroid, suggesting that the course of the disease can be treatment modified.
外阴硬化性苔藓是一种重要的皮肤病,常见于 50 多岁及以上的女性;然而,它也可能影响任何年龄段的女性,包括儿童。如果不治疗,它有可能导致外阴结构的显著和永久性瘢痕和畸形。此外,如果不治疗,它与外阴鳞癌的 2-6%终身风险相关。硬化性苔藓被认为是一种难以治疗的疾病;然而,通过早期使用局部皮质类固醇进行干预,严重并发症都有可能被预防,这表明疾病的进程可以通过治疗来改变。