Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Amendola, 2, Pad. Besta, 42122, Reggio Emilia, Italy.
Biotechnol Lett. 2018 Oct;40(9-10):1289-1302. doi: 10.1007/s10529-018-2591-7. Epub 2018 Jul 10.
Acetic acid bacteria are versatile organisms converting a number of carbon sources into biomolecules of industrial interest. Such properties, together with the need to limit chemical syntheses in favor of more sustainable biological processes, make acetic acid bacteria appropriate organisms for food, chemical, medical, pharmaceutical and engineering applications. At current, well-established bioprocesses by acetic acid bacteria are those derived from the oxidative pathways that lead to organic acids, ketones and sugar derivates. Whereas emerging applications include biopolymers, such as bacterial cellulose and fructans, which are getting an increasing interest for the biotechnological industry. However, considering the industrial demand of high performing bioprocesses, the production yield of metabolites obtained by acetic acid bacteria, is still not satisfying. In this paper we review the major acetic acid bacteria industrial applications, considering the current status of bioprocesses. We will also describe new biotechnological advances in order to optimize the industrial production, offering also an overview on future directions.
醋酸菌是一种多功能的生物体,可以将许多碳源转化为具有工业价值的生物分子。这些特性,以及限制化学合成以支持更可持续的生物过程的需求,使得醋酸菌成为食品、化学、医疗、制药和工程应用的合适生物。目前,通过醋酸菌建立的成熟生物工艺是那些来自于导致有机酸、酮和糖衍生物的氧化途径。而新兴的应用包括生物聚合物,如细菌纤维素和果聚糖,它们越来越受到生物技术行业的关注。然而,考虑到高性能生物工艺的工业需求,醋酸菌获得的代谢产物的生产产量仍然不尽如人意。在本文中,我们将回顾醋酸菌的主要工业应用,同时考虑到生物工艺的现状。我们还将描述新的生物技术进展,以优化工业生产,并对未来的发展方向进行概述。