DTU Bioengineering, Søltofts Plads, DK-2800 Kgs, Lyngby, Denmark.
Department of Biotechnology, GIT, GITAM University, Visakhapatnam, AP, India.
Microbiol Res. 2018 Mar;207:83-90. doi: 10.1016/j.micres.2017.11.013. Epub 2017 Nov 21.
Yeast is very well known eukaryotic organism for its remarkable biodiversity and extensive industrial applications. Saccharomyces cerevisiae is one of the most widely used microorganisms in biotechnology with successful applications in the biochemical production. Biological conversion with the focus on the different utilization of renewable feedstocks into fuels and chemicals has been intensively investigated due to increasing concerns on sustainability issues worldwide. Compared with its counterparts, Saccharomyces cerevisiae, the baker's yeast, is more industrially relevant due to known genetic and physiological background, the availability of a large collection of genetic tools, the compatibility of high-density and large-scale fermentation, and optimize the pathway for variety of products. Therefore, S. cerevisiae is one of the most popular cell factories and has been successfully used in the modern biotech industry to produce a wide variety of products such as ethanol, organic acids, amino acids, enzymes, and therapeutic proteins. This study explores how different sustainable solutions used to overcome various environmental effects on yeast. This work targets a broad matrix of current advances and future prospect in yeast biotechnology and discusses their application and potential in general.
酵母是一种非常知名的真核生物，具有显著的生物多样性和广泛的工业应用。酿酒酵母是生物技术中应用最广泛的微生物之一，在生化生产中取得了成功。由于全球对可持续性问题的日益关注，以不同可再生原料为重点的生物转化为燃料和化学品的研究受到了广泛关注。与其他酵母相比，面包酵母酿酒酵母由于其已知的遗传和生理背景、大量遗传工具的可用性、高密度和大规模发酵的兼容性以及优化各种产品途径的能力，更具有工业相关性。因此，酿酒酵母是最受欢迎的细胞工厂之一，已成功用于现代生物技术工业，生产各种产品，如乙醇、有机酸、氨基酸、酶和治疗性蛋白质。本研究探讨了如何使用不同的可持续解决方案来克服酵母对各种环境影响。这项工作针对酵母生物技术的当前进展和未来前景的广泛矩阵，并讨论了它们的一般应用和潜力。
