REQUIMTE/CQFB, Chemistry Department, FCT/Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Trends Biotechnol. 2011 Aug;29(8):388-98. doi: 10.1016/j.tibtech.2011.03.008. Epub 2011 May 10.
A vast number of bacterial extracellular polysaccharides (EPSs) have been reported over recent decades, and their composition, structure, biosynthesis and functional properties have been extensively studied. Despite the great diversity of molecular structures already described for bacterial EPSs, only a few have been industrially developed. The main constraints to full commercialization are their production costs, mostly related to substrate cost and downstream processing. In this article, we review EPS biosynthetic and fermentative processes, along with current downstream strategies. Limitations and constraints of bacterial EPS development are stressed and correlation of bacterial EPS properties with polymer applications is emphasized.
近几十年来，人们已经报道了大量的细菌胞外多糖（EPS），其组成、结构、生物合成和功能特性已经得到了广泛的研究。尽管已经描述了细菌 EPS 的分子结构具有很大的多样性，但只有少数得到了工业开发。完全商业化的主要限制因素是它们的生产成本，主要与底物成本和下游加工有关。本文综述了 EPS 的生物合成和发酵过程，以及当前的下游策略。强调了细菌 EPS 开发的局限性和制约因素，并强调了细菌 EPS 特性与聚合物应用的相关性。
