Riches David W H, Martin Thomas R
Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Division of Pulmonary, Critical and Sleep Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Methods Mol Biol. 2018;1809:17-30. doi: 10.1007/978-1-4939-8570-8_2.
The nasal passages, conducting airways and gas-exchange surfaces of the lung, are constantly exposed to substances contained in the air that we breathe. While many of these suspended substances are relatively harmless, some, for example, pathogenic microbes, noxious pollutants, and aspirated gastric contents can be harmful. The innate immune system, lungs and conducting airways have evolved specialized mechanisms to protect the respiratory system not only from these harmful inhaled substances but also from the overly exuberant innate immune activation that can arise during the host response to harmful inhaled substances. Herein, we discuss the cell types that contribute to lung innate immunity and inflammation and how their activities are coordinated to promote lung health.
鼻腔通道、肺的传导气道和气体交换表面，不断暴露于我们所呼吸空气中所含的物质。虽然这些悬浮物质中的许多相对无害，但有些物质，例如致病微生物、有害污染物和误吸的胃内容物可能是有害的。先天性免疫系统、肺和传导气道已经进化出专门的机制，以保护呼吸系统不仅免受这些有害吸入物质的侵害，而且免受宿主对有害吸入物质反应过程中可能出现的过度旺盛的先天性免疫激活。在此，我们讨论有助于肺先天性免疫和炎症的细胞类型，以及它们的活动如何协调以促进肺健康。
