Pp Bassareo, V Namana, M Puddu, S Marras, V Fanos, G Mercuro
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Maimonides Medical Center, New York,(NY) USA.
J Atr Fibrillation. 2018 Apr 30;10(6):1857. doi: 10.4022/jafib.1857. eCollection 2018 Apr.
Recent published data demonstrated how subjects born preterm are at higher risk of developing early atrial fibrillation (AF).
The surface ECG of twenty-four adults, former preterm infants born with an extremely low birth weight (ex-ELBW; mean age at study: 23.2±3.3 years; mean gestational age: 27.8±2.3 weeks; mean birth weight: 840±120.1 grams), were compared with those of 24 healthy counterparts born at term (C). A few parameters known to be capable of predicting a predisposition to develop AF were examined: P wave duration and dispersion, P terminal force, isoelectric interval length, PR interval length, and advanced interatrial blocks.
A shorter PR interval length was found in ex-ELBW compared to C (p<0.0003) as well as longer P wave duration and dispersion, p terminal force, and isoelectric interval (p<0.0001, p<0.0001, p<0.01, and p<0.0004, respectively). Four cases of advanced interatrial block were detected in ex-ELBW, and none in C (p<0.0001). P wave duration, PR interval length, and P wave dispersion were significantly correlated with birth weight (r=0.51 p<0.01, r=0.46 p<0.02, and r=0.42 p<0.04, respectively). When excluding the possible influence of gestational age on birth weight, P wave duration and dispersion were found to be the only statistically significant determinants of abnormal atrial electrical activation (p<0.03 and p<0.04, respectively). On the contrary, when excluding the possible influence of birth weight on gestational age, only P wave duration remained statistically significant (p<0.05).
Surface ECG findings of abnormal atrial activity in ex-ELBW may explain their previously reported predisposition to developing AF.
最近发表的数据表明，早产出生的个体发生早期心房颤动（AF）的风险更高。
将24名极低出生体重的成年前早产儿（极早早产儿；研究平均年龄：23.2±3.3岁；平均胎龄：27.8±2.3周；平均出生体重：840±120.1克）的体表心电图与24名足月出生的健康对照者（C组）的心电图进行比较。研究了一些已知能够预测发生AF易感性的参数：P波持续时间和离散度、P波终末电势、等电位间期长度、PR间期长度以及高级心房阻滞。
与C组相比，极早早产儿的PR间期长度较短（p<0.0003）以及P波持续时间和离散度、P波终末电势和等电位间期较长（分别为p<0.0001、p<0.0001、p<0.01和p<0.0004）。在极早早产儿中检测到4例高级心房阻滞，而C组未检测到（p<0.0001）。P波持续时间、PR间期长度和P波离散度与出生体重显著相关（分别为r=0.51，p<0.01；r=0.46，p<0.
