Kim Soo Kyoung, Bae Ji Cheol, Baek Jong-Ha, Jee Jae Hwan, Hur Kyu Yeon, Lee Moon-Kyu, Kim Jae Hyeon
Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
Institute of Health Sciences, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
PLoS One. 2017 Mar 27;12(3):e0174228. doi: 10.1371/journal.pone.0174228. eCollection 2017.
This study was conducted to investigate whether baseline lung function or change in lung function is associated with the development of metabolic syndrome (MS) in Koreans. We analyzed clinical and laboratory data from 3,768 Koreans aged 40-60 years who underwent medical check-ups over a six-year period between 2006 and 2012. We calculated the percent change in forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) over the study period. We tested for an association between baseline lung function or lung function change during the follow-up period and the development of MS. The 533 subjects (14.1%) developed MS after the six-year follow-up. The baseline FVC and FEV1 were not different between the subjects who developed MS after six years and the subject without MS after six years. The percent change in FVC over six years in subjects who developed MS after six years was higher than that in subjects who did not develop MS (-5.75 [-10.19 --1.17], -3.29 [-7.69-1.09], respectively, P = 0.001). The percent change in FVC over six years was associated with MS development after adjusting for age, sex, body mass index (BMI), glucose, HDL, triglyceride, waist circumferences (WC), and systolic blood pressure. However, these association was not significant after adjusting for change of BMI and change of WC over six years (P = 0.306). The greater change in vital capacity over six years of follow-up was associated with MS development, predominantly due to obesity and abdominal obesity. The prospective study is needed to determine the relationship between lung function decline and MS.
本研究旨在调查韩国人基线肺功能或肺功能变化是否与代谢综合征（MS）的发生有关。我们分析了2006年至2012年期间接受医学检查的3768名40 - 60岁韩国人的临床和实验室数据。我们计算了研究期间用力肺活量（FVC）和第1秒用力呼气量（FEV1）的变化百分比。我们测试了基线肺功能或随访期间肺功能变化与MS发生之间的关联。533名受试者（14.1%）在六年随访后发生了MS。六年后患MS的受试者与六年未患MS的受试者之间的基线FVC和FEV1没有差异。六年后患MS的受试者在六年内FVC的变化百分比高于未患MS的受试者（分别为-5.75 [-10.19 --1.17]，-3.29 [-7.69 - 1.09]，P = 0.001）。在调整年龄、性别、体重指数（BMI）、血糖、高密度脂蛋白、甘油三酯、腰围（WC）和收缩压后，六年内FVC的变化百分比与MS的发生有关。然而，在调整六年内BMI和WC的变化后，这种关联并不显著（P = 0.306）。随访六年期间肺活量的更大变化与MS的发生有关，主要是由于肥胖和腹型肥胖。需要进行前瞻性研究来确定肺功能下降与MS之间的关系。
