Wei Chapman, Wei Chaplin, Alhalabi Omar, Chen Lei
George Washington University School of Medicine and Health Sciences at Washington, DC 20052, United States.
St. George's University School of Medicine, West Indies, Grenada.
World J Clin Cases. 2018 Jun 16;6(6):121-126. doi: 10.12998/wjcc.v6.i6.121.
T-cell/histiocyte-rich large B-cell lymphoma is uncommon in children population. There were few cases reported in the literature with wide range clinical presentations including advanced stage, and more involvement of liver, spleen and bone marrow. Head and neck lymphadenopathy tends to present in younger children. We report a case of 10-year-old boy who initially presented intermittent fever, headaches and neck lymphadenopathy. Subsequently, he developed diffuse lymphadenopathy and hepatosplenomegaly. T-cell/histiocyte-rich large B-cell lymphoma was diagnosed on a cervical lymph node biopsy. Cervical lymphadenopathy in this age group is most commonly reactive or non-malignant processes. Lymphoma is much less frequent; mainly are non-Hodgkin lymphomas. However, a subset of large B-cell lymphoma called T-cell/histiocyte- rich B-cell lymphoma is rare in children.
富于T细胞/组织细胞的大B细胞淋巴瘤在儿童中并不常见。文献中报道的病例很少，临床表现范围广泛，包括晚期，肝脏、脾脏和骨髓受累较多。头颈部淋巴结肿大往往出现在年幼儿童中。我们报告一例10岁男孩，最初表现为间歇性发热、头痛和颈部淋巴结肿大。随后，他出现了全身淋巴结肿大和肝脾肿大。经颈部淋巴结活检诊断为富于T细胞/组织细胞的大B细胞淋巴瘤。这个年龄组的颈部淋巴结肿大最常见的是反应性或非恶性病变。淋巴瘤则少见得多；主要是非霍奇金淋巴瘤。然而，一种称为富于T细胞/组织细胞的大B细胞淋巴瘤的亚型在儿童中很罕见。
