Kunnas Tarja, Solakivi Tiina, Nikkari Seppo T
Department of Medical Biochemistry, Faculty of Medicine and Life Sciences, Fimlab Laboratories, University of Tampere, Tampere, Finland.
Mol Genet Genomic Med. 2018 Sep;6(5):828-834. doi: 10.1002/mgg3.450. Epub 2018 Jul 10.
We examined the association of three known genome-wide association study loci for blood lipids that have lead traits for triglycerides with hypertension in the Tampere adult population cardiovascular risk study.
A Finnish cohort of 190 men with diagnosed hypertension and 279 controls were analyzed. Samples were genotyped for low-density lipoprotein receptor-related protein 1 rs11613352 (C>T), angiopoietin-like 3 rs2131925 (T>G), and fatty acid desaturase 1 rs174546 (C>T) polymorphisms using competitive allele-specific polymerase chain reaction technique.
At the age of 50, subjects with low-density lipoprotein receptor-related protein 1 rs11613352 (C>T) minor genotype TT had significantly more hypertension than those with the C allele (OR 5.17, CI 2.03-12.74, p < 0.001). Subjects with angiopoietin-like 3 rs2131925 (T>G) T allele had more hypertension than those with the minor genotype GG (OR 5.02, CI 1.40-17.98, p = 0.013). Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension.
Association of low-density lipoprotein receptor-related protein 1 rs11613352 and angiopoietin-like 3 rs2131925 with hypertension might imply a direct effect at the artery wall.
在坦佩雷成年人群心血管风险研究中，我们研究了三个已知的全基因组关联研究血脂位点（这些位点以甘油三酯为主要特征）与高血压之间的关联。
对芬兰一组190名已确诊高血压的男性和279名对照进行了分析。使用竞争性等位基因特异性聚合酶链反应技术，对低密度脂蛋白受体相关蛋白1 rs11613352（C>T）、血管生成素样3 rs2131925（T>G）和脂肪酸去饱和酶1 rs174546（C>T）多态性进行基因分型。
在50岁时，低密度脂蛋白受体相关蛋白1 rs11613352（C>T）次要基因型TT的受试者患高血压的比例显著高于携带C等位基因的受试者（比值比5.17，可信区间2.03 - 12.74，p < 0.001）。血管生成素样3 rs2131925（T>G）T等位基因的受试者患高血压的比例高于次要基因型GG的受试者（比值比5.02，可信区间1.40 - 17.98，p = 0.013）。脂肪酸去饱和酶1 rs174546（C>T）与高血压无关。
低密度脂蛋白受体相关蛋白1 rs11613352和血管生成素样3 rs2131925与高血压的关联可能意味着对动脉壁有直接影响。
