Health Management Center, Tianjin Medical University General Hospital, Tianjin, China.
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
J Dig Dis. 2018 Aug;19(8):498-507. doi: 10.1111/1751-2980.12646. Epub 2018 Aug 23.
Few studies have reported the association between nonalcoholic fatty liver disease (NAFLD) and immunoglobulins. In this study, we aimed to investigate the relationship between serum immunoglobulin levels and NAFLD in a Chinese adult population.
We performed a cross-sectional study including 11 261 Chinese adults. NAFLD was diagnosed based on the Chinese Guidelines for the diagnosis and treatment of fatty liver diseases and an alcohol intake of <70 g/week in women and <140 g/week in men, and serum immunoglobulin (Ig) levels were determined using immune nephelometry. Multiple logistic regression analysis was done to assess relationships between concentrations of serum immunoglobulins and NAFLD.
Of the 11 261 adults recruited from January 2010 to December 2015, the prevalence of NAFLD was 40.8% (n = 4598). The geometric mean levels of IgG, IgM, IgE and IgA were 1177.49 mg/dL (95% confidence interval [CI] 1173.07-1181.93), 93.56 mg/dL (95% CI 92.70-94.42), 30.70 IU/mL (95% CI 29.92-31.49) and 216.64 mg/dL (95% CI 214.95-218.34), respectively. Compared with the lowest quintile, the multivariable adjusted odds ratio (95% CI) of NAFLD for the highest quintile of IgG, IgM, IgE, and IgA were 0.78 (0.66-0.92), 0.71 (0.60-0.84), 0.98 (0.84-1.15) and 1.41 (1.21-1.66), respectively.
Increased IgA and decreased IgG and IgM levels are independently associated with NAFLD prevalence. Further research is needed to explore the causal association between serum immunoglobulins and NAFLD.
很少有研究报道非酒精性脂肪性肝病（NAFLD）与免疫球蛋白之间的关系。本研究旨在调查中国成年人群血清免疫球蛋白水平与 NAFLD 之间的关系。
我们进行了一项横断面研究，纳入了 11261 名中国成年人。NAFLD 根据中国脂肪性肝病诊断和治疗指南以及女性每周酒精摄入量<70g 和男性每周酒精摄入量<140g 进行诊断，使用免疫散射比浊法测定血清免疫球蛋白（Ig）水平。采用多因素 logistic 回归分析评估血清免疫球蛋白浓度与 NAFLD 之间的关系。
在 2010 年 1 月至 2015 年 12 月期间招募的 11261 名成年人中，NAFLD 的患病率为 40.8%（n=4598）。IgG、IgM、IgE 和 IgA 的几何均数水平分别为 1177.49mg/dL（95%置信区间[CI]1173.07-1181.93）、93.56mg/dL（95%CI92.70-94.42）、30.70IU/mL（95%CI29.92-31.49）和 216.64mg/dL（95%CI214.95-218.34）。与最低五分位相比，IgG、IgM、IgE 和 IgA 最高五分位的多变量调整比值比（95%CI）分别为 0.78（0.66-0.92）、0.71（0.60-0.84）、0.98（0.84-1.15）和 1.41（1.21-1.66）。
IgA 升高和 IgG、IgM 降低与 NAFLD 患病率独立相关。需要进一步研究以探讨血清免疫球蛋白与 NAFLD 之间的因果关系。
