Olewicz-Gawlik Anna, Polańska Adriana, Trzybulska Dorota, Nowak-Gabryel Michalina, Błochowiak Katarzyna, Kocięcki Jarosław, Sokalski Jerzy, Żaba Ryszard, Adamski Zygmunt, Dańczak-Pazdrowska Aleksandra
Adriana Polańska, MD, Department of Dermatology and Venereology, Poznań University of Medical Sciences, Poznan, Poland;
Acta Dermatovenerol Croat. 2018 Jun;26(2):153-156.
Sjögren's syndrome (SS) is a systemic autoimmune disease. A large percentage of patients with SS suffer from dry skin, the cause and pathogenesis of which in this group of patients remains obscure. The aim of the present study was to investigate skin barrier function in patients with SS. Measurements of transepidermal water loss (TEWL) and hydration of stratum corneum (corneometry, CM) were performed in 30 female patients with SS (17 with primary SS and 13 with secondary SS), 20 patients with atopic dermatitis (AD) and 14 healthy controls. There were no statistically significant differences in TEWL values between the three investigated groups, while CM values were significantly decreased in patients with AD when compared with patients with SS and the healthy controls. Based on the obtained results, skin barrier function and hydration in patients with SS showed no functional alterations.
干燥综合征（SS）是一种全身性自身免疫性疾病。很大一部分SS患者存在皮肤干燥问题，该类患者中皮肤干燥的病因及发病机制仍不清楚。本研究的目的是调查SS患者的皮肤屏障功能。对30例女性SS患者（17例原发性SS和13例继发性SS）、20例特应性皮炎（AD）患者和14名健康对照者进行了经表皮水分流失（TEWL）测定和角质层水合作用（角质层测厚仪，CM）测量。三个研究组之间的TEWL值无统计学显著差异，而与SS患者和健康对照者相比，AD患者的CM值显著降低。根据所得结果，SS患者的皮肤屏障功能和水合作用未显示功能改变。
