EZH2 通过失活初级纤毛来激活 Wnt 信号通路并驱动黑色素瘤发生。
EZH2 Inactivates Primary Cilia to Activate Wnt and Drive Melanoma.
机构信息
Baxter Laboratory, Department of Microbiology and Immunology and Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Cancer Cell. 2018 Jul 9;34(1):3-5. doi: 10.1016/j.ccell.2018.06.011.
PMID:29990499
Abstract
EZH2 is frequently amplified in human melanomas. In this issue of Cancer Cell, Zingg et al. find that EZH2 overexpression silences genes for the primary cilium, causing deciliation, Wnt pathway activation, and progression of Braf- or Nras-driven melanomas, thus defining a tumor-suppressor role for cilia in cancer.
摘要
EZH2 在人类黑色素瘤中经常被扩增。在本期《癌细胞》中，Zingg 等人发现，EZH2 的过表达会使初级纤毛的基因沉默，导致纤毛消失、Wnt 通路激活以及 Braf 或 Nras 驱动的黑色素瘤的进展，从而定义了纤毛在癌症中的肿瘤抑制作用。
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