Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran.
Pharmacol Res. 2018 Sep;135:37-48. doi: 10.1016/j.phrs.2018.07.004. Epub 2018 Jul 7.
Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no drug of cure for these, mostly age-related diseases, although approaches in delaying the pathology and/or giving patients some symptomatic relief have been adopted for the last few decades. Various studies in recent years have shown the beneficial effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse mechanisms including anti-inflammatory effects. This review now assesses the potential of this class of compounds in NDs therapy through specific action against the mammalian target of rapamycin (mTOR) signaling pathway. The role of mTOR in neurodegenerative diseases and targeted therapies by PUFAs are discussed.
神经退行性疾病（NDs），如帕金森病（PD）、阿尔茨海默病（AD）、亨廷顿病（HD）和肌萎缩侧索硬化症（ALS），导致了全球范围内的高发病率和死亡率。迄今为止，尽管在过去几十年中，已经采取了一些延缓病理和/或为患者提供一些症状缓解的方法，但对于这些主要与年龄相关的疾病，仍然没有治愈的药物。近年来的多项研究表明，ω-3 多不饱和脂肪酸（PUFAs）通过多种机制，包括抗炎作用，具有有益的效果。本综述通过针对哺乳动物雷帕霉素靶蛋白（mTOR）信号通路的特定作用，评估了这类化合物在 NDs 治疗中的潜力。讨论了 mTOR 在神经退行性疾病中的作用以及 PUFAs 的靶向治疗。
