Department of Life Sciences, Modena and Reggio Emilia University, 41125 Modena, Italy.
Division of Geriatric Medicine, Department of Biomedical, Metabolic and Neural Sciences, and Center for Gerontological Evaluation and Research, Modena and Reggio Emilia University, 41126 Modena, Italy.
Int J Mol Sci. 2019 Aug 30;20(17):4256. doi: 10.3390/ijms20174256.
A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, since there is no effective therapy for these diseases so far. The beneficial effects of omega-3 fatty acids are now well established by a plethora of studies through their involvement in multiple biochemical functions, including synthesis of anti-inflammatory mediators, cell membrane fluidity, intracellular signaling, and gene expression. This systematic review will consider epidemiological studies and clinical trials that assessed the impact of supplementation or dietary intake of omega-3 polyunsaturated fatty acids on neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Indeed, treatment with omega-3 fatty acids, being safe and well tolerated, represents a valuable and biologically plausible tool in the management of neurodegenerative diseases in their early stages.
营养方法可能是预防或减缓神经退行性疾病（如帕金森病和阿尔茨海默病）进展的有前途的策略，因为迄今为止，这些疾病还没有有效的治疗方法。大量研究表明，ω-3 脂肪酸通过参与多种生化功能（包括抗炎介质的合成、细胞膜流动性、细胞内信号转导和基因表达）发挥有益作用。本系统评价将考虑评估ω-3 多不饱和脂肪酸补充或饮食摄入对神经退行性疾病（如帕金森病和阿尔茨海默病）影响的流行病学研究和临床试验。事实上，ω-3 脂肪酸治疗安全且耐受性良好，代表了在神经退行性疾病早期阶段进行管理的有价值且合理的生物学工具。
