Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil.
Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil.
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Sep 1;1093-1094:82-90. doi: 10.1016/j.jchromb.2018.06.059. Epub 2018 Jul 3.
Parabens have been widely used as antimicrobial preservatives in food, drugs, and cosmetics for over 60 years. These endocrine disruptors can alter both the wildlife and the human hormone function. Determining these compounds in human milk is important because breast milk plays an important role in infant growth and in neurocognitive development. This article summarizes the current state-of-the-art of chromatographic methods to determine parabens in breast milk samples. Apart from the conventional and modern microextraction sample preparation techniques described herein, the authors discuss the chromatographic systems, primarily LC-MS/MS, and the concentration ranges at which parabens have been detected in milk samples obtained from lactating women over the past few years.
对羟基苯甲酸酯作为一种抗菌防腐剂，已在食品、药品和化妆品领域广泛使用超过 60 年。这些内分泌干扰物会改变野生动物和人类的激素功能。检测人乳中的这些化合物非常重要，因为母乳在婴儿的生长和神经认知发育中起着重要作用。本文总结了目前用于检测人乳中对羟基苯甲酸酯的色谱方法。除了本文中描述的传统和现代微萃取样品制备技术外，作者还讨论了色谱系统，主要是 LC-MS/MS，以及过去几年从哺乳期妇女获得的牛奶样品中检测到的对羟基苯甲酸酯的浓度范围。
