Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan..
J Inorg Biochem. 2018 Sep;186:264-266. doi: 10.1016/j.jinorgbio.2018.06.002. Epub 2018 Jun 7.
Cytochrome P450 (P450) of eukaryotes and prokaryotes diversified remarkably during the long course of their evolution. Since the diversification of P450 was the consequence of the adaptation of various living organisms to diverse environmental changes, the catalytic activities and physiological functions of the P450s of different taxa can be significantly different. It is likely that many P450s with novel physiological functions will be found in future when we further identify and examine the P450s of various eukaryotes and prokaryotes. The whole-genome sequences of a few thousand species are now available. The genome data will be helpful for the search of novel P450s in the eukaryotic and prokaryotic organisms that have not been studied so far. Discovery of new P450s with unique catalytic activities will expand the scope of biochemical and biophysical research on P450.
真核生物和原核生物的细胞色素 P450（P450）在其漫长的进化过程中发生了显著的多样化。由于 P450 的多样化是各种生物适应不同环境变化的结果，因此不同分类群的 P450 的催化活性和生理功能可能有很大的不同。当我们进一步鉴定和研究各种真核生物和原核生物的 P450 时，很可能会发现许多具有新生理功能的 P450。现在已经有几千个物种的全基因组序列。基因组数据将有助于在迄今尚未研究的真核生物和原核生物中搜索新型 P450。发现具有独特催化活性的新型 P450 将扩大对 P450 的生化和生物物理研究范围。
