育龄期不孕妇女卵巢储备功能与甲状腺激素水平的相关性分析。
Correlation Analysis Between Ovarian Reserve and Thyroid Hormone Levels in Infertile Women of Reproductive Age.
机构信息
Department of Clinical Laboratory, Fushun Maternal and Child Health Hospital, Fushun, China.
Department of Reproductive Technology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
出版信息
Front Endocrinol (Lausanne). 2021 Sep 27;12:745199. doi: 10.3389/fendo.2021.745199. eCollection 2021.
OBJECTIVE
To analyze the correlation between ovarian reserve and thyroid function in women with infertility.
METHODS
Retrospective analysis of the data of 496 infertility patients who visited the clinic between January 2019 and December 2020. According to the TSH level, it is grouped into <2.5 mIU/L, 2.5~4.0mIU/L and ≥4.0 mIU/L or according to the positive/negative thyroid autoimmune antibody. The relationship was assessed through the ovarian reserve, thyroid function, and anti-Müllerian hormone (AMH) levels in infertile patients. On the other hand, the patients are divided into groups according to age (≤29 years old, 30-34 years old and ≥35 years old), basic FSH (<10 IU/L and ≥10 IU/L), and AMH levels. The ovarian reserve was evaluated through the AMH and the antral follicle count (AFC).
RESULTS
The average age of the patients was 30.31 ± 4.50 years old, and the average AMH level was 5.13 ± 4.30 ng/mL. 3.63% (18/496) of patients had abnormal TSH levels (normal: 0.35-5.5 mIU/L), the positive rate of thyroid peroxidase antibody (TPOAb) was 14.52% (72/496), the positive rate of anti-thyroglobulin antibody (TgAb) was 16.94% (84/496), and the positive rate of TPOAb and TgAb was 10.48% (52/496). After grouping according to TSH level or thyroid autoimmune antibody positive/negative grouping, the analysis found that there was no statistical significance in age, AMH level and basic FSH level among the groups (P>0.05). There were no significant differences in the levels of TSH, FT3, and FT4 among different ages, AMH, and FSH levels (P>0.05).
CONCLUSION
There is no significant correlation between ovarian reserve and thyroid function in infertile women.
目的
分析不孕妇女卵巢储备功能与甲状腺功能的相关性。
方法
回顾性分析 2019 年 1 月至 2020 年 12 月间就诊的 496 例不孕患者的数据。根据 TSH 水平，分为<2.5mIU/L、2.5~4.0mIU/L 和≥4.0mIU/L 或根据甲状腺自身抗体的阳性/阴性分组。通过评估不孕患者的卵巢储备、甲状腺功能和抗苗勒管激素（AMH）水平来评估两者之间的关系。另一方面，根据年龄（≤29 岁、30-34 岁和≥35 岁）、基础 FSH（<10IU/L 和≥10IU/L）和 AMH 水平将患者分为不同组。通过 AMH 和窦卵泡计数（AFC）评估卵巢储备。
结果
患者平均年龄为 30.31±4.50 岁，平均 AMH 水平为 5.13±4.30ng/ml。496 例患者中，3.63%（18/496）TSH 水平异常（正常：0.35-5.5mIU/L），甲状腺过氧化物酶抗体（TPOAb）阳性率为 14.52%（72/496），抗甲状腺球蛋白抗体（TgAb）阳性率为 16.94%（84/496），TPOAb 和 TgAb 阳性率为 10.48%（52/496）。根据 TSH 水平或甲状腺自身抗体阳性/阴性分组后进行分组，分析发现各组间年龄、AMH 水平和基础 FSH 水平无统计学意义（P>0.05）。不同年龄、AMH 和 FSH 水平的 TSH、FT3 和 FT4 水平无显著差异（P>0.05）。
结论
不孕妇女卵巢储备功能与甲状腺功能无显著相关性。
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