Department of Scientific Research and Development, Velleja Research, Milan, Italy -
Department of Health Sciences, University of Genoa, Genoa, Italy.
Panminerva Med. 2018 Dec;60(4):156-160. doi: 10.23736/S0031-0808.18.03518-8. Epub 2018 Jul 10.
Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. Several trials have found hypericum to be more effective than placebo or some antidepressant drugs, but the exact mechanism and most relevant compounds are still unclear. A possible hypothesis is that the antidepressant activity might be due to its multiplicity of bioactive compounds. Aim is to test if greater chemical complexity could result in a greater hypericum antidepressant action.
A retrospective, 12-month, open-label, observational, controlled trial was conducted to compare the antidepressant clinical activity of a conventional Hypericum perforatum (C-Hp) versus a multi-fractionated (M-Hp) one (IperiPlex®).
Treatment with C-Hp demonstrated no efficacy after 6 months and partial (P<0.05) efficacy after 12 months. Treatment with MF-Hp demonstrated highly (P<0.01) significant results at both 6 and 12 months. Analysis of the monthly reduction coefficient demonstrated that treatment with MF-Hp was twice as effective as treatment with C-Hp (0.96 versus 0.48). No side effects were reported.
A multi-fractionated hypericum extract has better clinical outcomes in subjects with depression without determining an increased risk of toxicity or reduced tolerability.
贯叶金丝桃被用作治疗轻度至中度抑郁症的药用植物。多项试验发现贯叶金丝桃比安慰剂或某些抗抑郁药更有效，但确切的机制和最相关的化合物仍不清楚。一种可能的假设是，抗抑郁活性可能是由于其多种生物活性化合物。目的是检验化学复杂性的增加是否会导致贯叶金丝桃更强的抗抑郁作用。
进行了一项回顾性、12 个月、开放性、标记、对照试验，比较了常规贯叶金丝桃（C-Hp）与多馏分（M-Hp）（IperiPlex®）的抗抑郁临床活性。
C-Hp 治疗 6 个月后无疗效，12 个月后部分（P<0.05）有效。MF-Hp 治疗 6 个月和 12 个月均有高度显著（P<0.01）的疗效。每月减少系数分析表明，MF-Hp 治疗的效果是 C-Hp 的两倍（0.96 与 0.48）。未报告不良反应。
多馏分贯叶金丝桃提取物在抑郁症患者中具有更好的临床疗效，而不会增加毒性风险或降低耐受性。
