Chen Shen, Tang Yueheng, Gao Yang, Nie Kexin, Wang Hongzhan, Su Hao, Wang Zhi, Lu Fuer, Huang Wenya, Dong Hui
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Grade 2017 of Integrated Traditional Chinese and Western Clinical Medicine, Second Clinical School, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2022 Apr 8;13:865376. doi: 10.3389/fphar.2022.865376. eCollection 2022.
Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients. Quercetin is a flavonol present in fruits, vegetables, and Traditional Chinese medicine (TCM) that has been proved to have various pharmacological effects such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, and neuroprotective. This review summarizes the evidence for the pharmacological application of quercetin to treat depression. We clarified the mechanisms of quercetin regulating the levels of neurotransmitters, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and reducing inflammatory states and anti-oxidative stress. We also summarized the antidepressant effects of some quercetin glycoside derivatives to provide a reference for further research and clinical application.
抑郁症是一个全球性的健康问题，其患病率不断上升，对患者的日常生活产生严重影响。然而，目前使用的抗抑郁药的副作用大大降低了患者的依从性。槲皮素是一种存在于水果、蔬菜和中药中的黄酮醇，已被证明具有多种药理作用，如抗抑郁、抗癌、抗菌、抗氧化、抗炎和神经保护作用。本综述总结了槲皮素在治疗抑郁症方面的药理应用证据。我们阐明了槲皮素调节神经递质水平、促进海马神经元再生、改善下丘脑-垂体-肾上腺（HPA）轴功能障碍以及减轻炎症状态和抗氧化应激的机制。我们还总结了一些槲皮素糖苷衍生物的抗抑郁作用，为进一步的研究和临床应用提供参考。
