Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, 94158, USA.
Cancer Immunology, Genentech, Inc., South San Francisco, CA, 94080, USA.
Cell Death Differ. 2018 Aug;25(8):1530-1531. doi: 10.1038/s41418-018-0155-y. Epub 2018 Jul 10.
Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activation upon ER stress.
几项研究表明，特定的死亡受体（DRs）和半胱天冬酶-8 在介导内质网（ER）应激反应中的细胞凋亡中起作用；然而，最近的一篇论文对这一结论提出了挑战。在这里，我们验证了 DR5 和半胱天冬酶-8 作为 ER 应激时细胞凋亡激活的关键信号传导物的重要性。
