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细菌衍生的牛α干扰素I1对特定牛病毒的体外保护作用

In vitro protective effect of bacteria-derived bovine alpha interferon I1 against selected bovine viruses.

作者信息

Gillespie J H, Robson D S, Scott F W, Schiff E I

出版信息

J Clin Microbiol. 1985 Dec;22(6):912-4. doi: 10.1128/jcm.22.6.912-914.1985.

DOI:10.1128/jcm.22.6.912-914.1985

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC271850/

Abstract

We used bacteria-derived bovine alpha-interferon I1 (Bo IFN-alpha I1) to study its antiviral effect in a bovine turbinate cell line on bovine diarrhea virus, infectious bovine rhinotracheitis virus, parainfluenza 3 virus, and pseudorabies virus. We based our study upon replicate tests for each strain by using a block titration system with various concentrations of Bo IFN-alpha I1 against various concentrations of virus. The data were compiled in two-axis tables (replicate X concentration) and were statistically analyzed by the Spearman-Kärber method. An increase in the concentration of Bo IFN-alpha I1 enhanced its protective effect against every test virus strain. Bo IFN-alpha I1 had a marked in vitro effect on the bovine diarrhea viral strains. It demonstrated less protection against the pseudorabies and parainfluenza 3 viruses. Its effectiveness against the two infectious bovine rhinotracheitis viral strains was lesser and of a low order.

摘要

我们使用细菌衍生的牛α干扰素I1（Bo IFN-α I1）来研究其在牛鼻甲细胞系中对牛腹泻病毒、牛传染性鼻气管炎病毒、副流感3病毒和伪狂犬病病毒的抗病毒作用。我们的研究基于对每个毒株的重复试验，采用了针对不同浓度病毒的不同浓度Bo IFN-α I1的区组滴定系统。数据被整理成两轴表格（重复X浓度），并通过Spearman-Kärber方法进行统计分析。Bo IFN-α I1浓度的增加增强了其对每种测试病毒毒株的保护作用。Bo IFN-α I1对牛腹泻病毒毒株具有显著的体外作用。它对伪狂犬病和副流感3病毒的保护作用较小。其对两种牛传染性鼻气管炎病毒毒株的有效性较低且程度不高。