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一名患有高雄激素血症、胰岛素抵抗和黑棘皮症（HAIR-AN综合征）的患者出现化脓性汗腺炎。

Hidradenitis suppurativa in a patient with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome).

作者信息

Melibary Yaser Taha

机构信息

Private Clinic for Dermatology, Allergy and Aesthetic Medicine, Coesfeld, Germany.

出版信息

Dermatol Reports. 2018 Jun 25;10(1):7546. doi: 10.4081/dr.2018.7546. eCollection 2018 Apr 23.

DOI:10.4081/dr.2018.7546
PMID:29991979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6026813/
Abstract

The author reports a rare presentation of hidradenitis supprutiva (HS) in combination with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome) in a female patient. Recently many clues have improved the understanding of HS as a systemic disease rather as a disease only with dermatological manifestation. This report might give another hint emphasizing the endocrinological and hormonal role in HS.

摘要

作者报告了一名女性患者中化脓性汗腺炎（HS）与高雄激素血症、胰岛素抵抗和黑棘皮病（HAIR-AN综合征）相结合的罕见表现。最近，许多线索加深了人们对HS作为一种全身性疾病而非仅具有皮肤表现的疾病的理解。本报告可能会提供另一个线索，强调内分泌和激素在HS中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3c/6026813/86f9c58e6b28/dr-10-1-7546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3c/6026813/86f9c58e6b28/dr-10-1-7546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3c/6026813/86f9c58e6b28/dr-10-1-7546-g001.jpg

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Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways.
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