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丘脑生殖细胞瘤:一项具有挑战性的诊断、病例报告及文献综述

Thalamic germinoma: a challenging diagnosis, case report and literature review.

作者信息

Khairy Sami, Khubrani Reham, Al-Dandan Sadeq, Alobaid Abdullah

机构信息

Department of Neurosurgery in King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center (KFSH&RC), Riyadh, Saudi Arabia.

出版信息

J Surg Case Rep. 2018 Jul 3;2018(7):rjy154. doi: 10.1093/jscr/rjy154. eCollection 2018 Jul.

DOI:10.1093/jscr/rjy154
PMID:29992007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6031045/
Abstract

The thalamus and basal ganglia are unusual locations for an intracranial germ cell tumors. We are reporting a rare case of thalamic germinoma in an 18-year-old male. Challenging presentation, radiological appearance and pathological finding after surgical intervention delayed the diagnosis and treatment. Also, we are providing an extensive literature review. Diagnosis of thalamic germinoma is challenging because of non-specific symptoms, rare location and inconclusive radiological findings. An early tissue diagnosis associated with good outcome.

摘要

丘脑和基底神经节是颅内生殖细胞肿瘤的不常见发病部位。我们报告一例18岁男性丘脑生殖细胞瘤的罕见病例。具有挑战性的临床表现、影像学表现以及手术干预后的病理结果延误了诊断和治疗。此外,我们还提供了广泛的文献综述。丘脑生殖细胞瘤的诊断具有挑战性,原因在于症状不具特异性、发病部位罕见以及影像学检查结果不明确。早期组织诊断与良好预后相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beec/6031045/769dd73f2ff8/rjy154f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beec/6031045/02141daa7e32/rjy154f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beec/6031045/769dd73f2ff8/rjy154f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beec/6031045/02141daa7e32/rjy154f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beec/6031045/769dd73f2ff8/rjy154f02.jpg

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本文引用的文献

1
Germinomas in the basal ganglia: magnetic resonance imaging classification and the prognosis.基底节生殖细胞瘤:磁共振成像分类与预后。
J Neurooncol. 2010 Sep;99(2):227-36. doi: 10.1007/s11060-010-0119-7. Epub 2010 Jan 20.
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Germinoma in the basal ganglia with an abnormal karyotype: case report and review of the literature.基底节区伴有异常核型的生殖细胞瘤:病例报告及文献复习
Childs Nerv Syst. 2010 May;26(5):707-12. doi: 10.1007/s00381-009-1007-3. Epub 2009 Oct 30.
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Atypical location of germinoma in basal ganglia in adolescents: radiological features and treatment outcomes.
Cureus. 2021 Dec 27;13(12):e20760. doi: 10.7759/cureus.20760. eCollection 2021 Dec.
青少年基底节生殖细胞瘤的非典型部位:放射学特征和治疗结果。
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Zhonghua Yi Xue Za Zhi (Taipei). 1997 Nov;60(5):259-64.
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So-called intracranial germ cell tumours: are they really of germ cell origin?所谓的颅内生殖细胞肿瘤:它们真的起源于生殖细胞吗?
Br J Neurosurg. 1995;9(3):391-401. doi: 10.1080/02688699550041395.