Oyagbemi Ademola Adetokunbo, Omobowale Temidayo Olutayo, Asenuga Ebunoluwa Racheal, Abiola John Olusoji, Adedapo Adeolu Alex, Yakubu Momoh Audu
Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
J Tradit Complement Med. 2017 Dec 7;8(3):396-409. doi: 10.1016/j.jtcme.2017.05.003. eCollection 2018 Jul.
Arsenic acid is one of the abundant environmental pollutants present in soil, water and the air. Undoubtedly, it has found its way to the food chain in which humans and animals are the final targets thereby causing arrays of disease conditions including cardiovascular and renal dysfunction. Hence, the use of phytochemicals present in medicinal plants has gained global acceptance as chemotherapeutic agents that can prevent, ameliorate, reverse or treat diseases. From our study, arsenic acid intoxication led to significant increase in heart rate (HR), QRS, together with prolonged QT and QTc interval. However, Kolaviron (KV) at the dosage of 100 and 200 mg/kg body weight reversed the aforementioned electrocardiographic (ECG) changes. KV pre-treatment also ameliorated cardiorenal dysfunction via significant reduction in cardiac and renal markers of oxidative stress such as malondialdehyde, hydrogen peroxide generation, myeloperoxidase activity and nitric oxide contents. Immunohistochemistry revealed expressions of renal C-reactive proteins (CRP) and expressions of anti-apoptotic protein BCL2 in KV treated rats. Furthermore, cardiac troponin I (CTnI) expressions were lower in KV treated rats. Taken together, KV mitigated arsenic-acid induced cardiovascular dysfunction via up-regulation of antioxidant defense system and down-regulation of inflammatory and apoptotic signaling pathways.
砷酸是土壤、水和空气中存在的丰富环境污染物之一。毫无疑问，它已进入食物链，人类和动物是最终目标，从而导致一系列疾病状况，包括心血管和肾功能障碍。因此，药用植物中存在的植物化学物质作为可以预防、改善、逆转或治疗疾病的化学治疗剂已获得全球认可。根据我们的研究，砷酸中毒导致心率（HR）、QRS显著增加，同时QT和QTc间期延长。然而，剂量为100和200mg/kg体重的可乐维隆（KV）逆转了上述心电图（ECG）变化。KV预处理还通过显著降低心脏和肾脏氧化应激标志物（如丙二醛、过氧化氢生成、髓过氧化物酶活性和一氧化氮含量）改善了心肾功能障碍。免疫组织化学显示KV处理的大鼠肾C反应蛋白（CRP）表达和抗凋亡蛋白BCL2表达。此外，KV处理的大鼠心脏肌钙蛋白I（CTnI）表达较低。综上所述，KV通过上调抗氧化防御系统和下调炎症和凋亡信号通路减轻了砷酸诱导的心血管功能障碍。
