Department of Environmental Health Engineering, School of Medical Sciences, Behbahan Faculty of Medical Sciences, Behbahan, Iran.
Department of Physiology, Behbahan Faculty of Medical Sciences, Behbahan, Iran.
Sci Rep. 2023 Apr 15;13(1):6146. doi: 10.1038/s41598-023-31978-x.
This study aimed to evaluate the effect of short-term exposure to heavy metals (HM) extracted from PM on CB in workers' population in an outdoor space located in southern Iran during a dust storm. At first, 44 healthy and non-smoking workers were selected. Then PM and Blood samples were collected before and after the dust storm. Finally, HMs associated with PM measured by ICP-MS and its effect on the CB, including fibrinogen, CRP, TNF-α, and BP were estimated by ANOVA, Pearson correlation, and Odd Ratio (OR) in SPSS23. Based on the results, the concentration of PM and extracted HM such as Cr, As, and Cd was higher than the WHO/EPA standards in dust storms they increased the CB and BP remarkably. Moreover, the level of fibrinogen, blood pressure (BP) and TNF-α in dust storms were higher than in normal conditions (p < 0.05, OR > 3). In addition, As and Cd decreased fibrinogen concentration and systolic BP, respectively. Whereas, TNF-α was associated with concentration of Pb (R = - 0.85) on normal days. Consequently, the HM on PM such as As, interferes with the level of investigated CB. These results considered a potential risk for the residents in the southern regions of Iran.
本研究旨在评估在伊朗南部 Dust Storm 期间，工人在户外环境中短期暴露于从 PM 中提取的重金属（HM）对 CB 的影响。首先，选择了 44 名健康且不吸烟的工人。然后，在风暴前后采集 PM 和血液样本。最后，通过 ICP-MS 测量与 PM 相关的 HM，并使用 SPSS23 中的 ANOVA、Pearson 相关和 Odds Ratio（OR）来评估其对 CB 的影响，包括纤维蛋白原、CRP、TNF-α 和 BP。结果表明，在 Dust Storm 中，PM 及其提取的 HM（如 Cr、As 和 Cd）的浓度高于世界卫生组织/美国环保署的标准，它们显著增加了 CB 和 BP。此外，在 Dust Storm 期间，纤维蛋白原、血压（BP）和 TNF-α的水平高于正常情况（p<0.05，OR>3）。此外，As 和 Cd 分别降低了纤维蛋白原浓度和收缩压。然而，在正常日，TNF-α与 Pb 浓度呈负相关（R=-0.85）。因此，PM 中的 HM 如 As 会干扰所研究的 CB 的水平。这些结果被认为是伊朗南部地区居民面临的潜在风险。
