Department of Orthopaedics, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, P.R. China.
Department of Traditional Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Brief Funct Genomics. 2019 Mar 22;18(2):140-146. doi: 10.1093/bfgp/ely022.
Cancer is a complex and refractory disease, which can disseminate from primary site to a different site even at an early stage. Cancer immunotherapy harnesses host immune system to battle against cancer, but only a minority of patients benefit from it. Genetic-based technologies have significantly promoted the development of cancer immunotherapy. Here we describe genetic-based cancer immunotherapies in three aspects: recombinant cancer vaccine, immune checkpoint blockade therapy and adoptive cell transfer. In the future, multi-disciplinary collaboration will greatly increase the scope and effectiveness of cancer immunotherpy.
癌症是一种复杂且难治的疾病，即使在早期阶段，也可能从原发部位扩散到其他部位。癌症免疫疗法利用宿主免疫系统来对抗癌症，但只有少数患者从中受益。基于基因的技术极大地促进了癌症免疫疗法的发展。在这里，我们从三个方面描述了基于基因的癌症免疫疗法：重组癌症疫苗、免疫检查点阻断疗法和过继细胞转移。在未来，多学科合作将极大地增加癌症免疫疗法的范围和效果。
