Klotman M E, Starnes D, Hamilton J D
J Infect Dis. 1985 Dec;152(6):1192-6. doi: 10.1093/infdis/152.6.1192.
The sources of cytomegalovirus (CMV) infection in kidney transplant recipients include reactivation of latent endogenous virus in the recipient or reactivation of latent virus in donated blood or kidney. In the present study, kidneys from mice latently infected with one strain of murine CMV were transplanted into either uninfected recipients or recipients latently infected with a different strain of murine CMV; the recipients were immunosuppressed, subsequently were cultured for murine CMV, and the infecting strain was characterized. The results show that reactivation of latent murine CMV from the donated kidney can be the source of active infection in previously uninfected recipients. When the recipient had been previously infected, however, reactivation of the endogenous recipient strain of murine CMV was the source of active infection in 10 of 12 instances. At no time were both exogenous and endogenous strains of virus reactivated simultaneously. These studies indicate that donor kidney may be the source of latent virus in the uninfected recipient but that endogenous virus predominates in previously infected recipients.
肾移植受者巨细胞病毒（CMV）感染的来源包括受者体内潜伏的内源性病毒重新激活，或捐献血液或肾脏中潜伏病毒的重新激活。在本研究中，将潜伏感染一种鼠巨细胞病毒株的小鼠肾脏移植到未感染的受者或潜伏感染不同鼠巨细胞病毒株的受者体内；对受者进行免疫抑制，随后培养鼠巨细胞病毒，并对感染株进行鉴定。结果表明，来自捐献肾脏的潜伏鼠巨细胞病毒重新激活可成为先前未感染受者活动性感染的来源。然而，当受者先前已被感染时，在12例中有10例，受者内源性鼠巨细胞病毒株的重新激活是活动性感染的来源。病毒的外源性和内源性株从未同时重新激活。这些研究表明，供体肾脏可能是未感染受者潜伏病毒的来源，但内源性病毒在先前感染的受者中占主导地位。
