Cvitanović Tomaš Tanja, Moškon Miha, Mraz Miha, Rozman Damjana
Acta Chim Slov. 2018 Jun;65(2):253-265. doi: 10.17344/acsi.2018.4461.
Computational models of liver metabolism are gaining an increasing importance within the research community. Moreover, their first clinical applications have been reported in recent years in the context of personalised and systems medicine. Herein, we survey selected experimental models together with the computational modelling approaches that are used to describe the metabolic processes of the liver in silico. We also review the recent developments in the large-scale hepatic computational models where we focus on object-oriented models as a part of our research. The object-oriented modelling approach is beneficial in efforts to describe the interactions between the tissues, such as how metabolism of the liver interacts with metabolism of other tissues via blood. Importantly, this modelling approach can account as well for transcriptional and post-translational regulation of metabolic reactions which is a difficult task to achieve. The current and potential clinical applications of large-scale hepatic models are also discussed. We conclude with the future perspectives within the systems and translational medicine research community.
肝脏代谢的计算模型在研究领域正变得越来越重要。此外，近年来在个性化和系统医学背景下已有其首次临床应用的报道。在此，我们概述了选定的实验模型以及用于在计算机上描述肝脏代谢过程的计算建模方法。我们还回顾了大规模肝脏计算模型的最新进展，其中我们将面向对象模型作为研究的一部分予以重点关注。面向对象建模方法有助于描述组织之间的相互作用，比如肝脏代谢如何通过血液与其他组织的代谢相互作用。重要的是，这种建模方法还能考虑代谢反应的转录和翻译后调控，而这是一项难以实现的任务。我们还讨论了大规模肝脏模型当前及潜在的临床应用。最后，我们展望了系统和转化医学研究领域的未来前景。
