a Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research , University of South Australia , Adelaide , South Australia , Australia.
Expert Opin Drug Saf. 2018 Aug;17(8):825-836. doi: 10.1080/14740338.2018.1497156. Epub 2018 Jul 19.
People with dementia may be particularly susceptible to medication-related problems for various reasons. They include progressive cognitive decline, high sensitivity to the effect of medications on cognition and memory, and increased likelihood of comorbidities.
This paper aimed to review current literature on the frequency and the types of medication-related problems, and their contribution to hospital admission in people with dementia. Literature searches were conducted using key search terms of dementia and medication-related problems. Studies investigating any medication-related problems in people with dementia or cognitive impairment were included.
Previous research showed a high prevalence of medication-related problems in people with dementia. However, no single category of medication-related problems was reported consistently as the most frequent type across studies. The available studies also showed that medication-related hospitalization was common among people with dementia. These findings underline the need for effective medication management services to reduce the risk of these problems in people with dementia and cognitive impairment. Further work is required to characterize medication-related problems comprehensively in this vulnerable patient group across settings of care. Future research should take a holistic approach in the identification of medication-related problems.
由于多种原因，痴呆患者可能特别容易出现与药物相关的问题。这些原因包括认知能力的逐渐下降、对药物对认知和记忆影响的高度敏感性以及合并症的可能性增加。
本文旨在回顾当前关于痴呆患者药物相关问题的频率和类型及其对住院的影响的文献。使用痴呆症和药物相关问题的关键搜索词进行文献检索。纳入了研究任何与痴呆或认知障碍患者相关的药物相关问题的研究。
先前的研究表明，痴呆患者中药物相关问题的发生率很高。然而，没有一项研究报告了药物相关问题的某一类别是最常见的类型。现有的研究还表明，药物相关的住院治疗在痴呆患者中很常见。这些发现强调了需要有效的药物管理服务，以降低痴呆和认知障碍患者出现这些问题的风险。需要进一步的工作来全面描述在不同护理环境下这一脆弱患者群体中的药物相关问题。未来的研究应该在确定药物相关问题时采取整体方法。
