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直肠癌新辅助治疗。

Neoadjuvant Therapy for Rectal Cancer.

机构信息

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

Dis Colon Rectum. 2018 Aug;61(8):883-886. doi: 10.1097/DCR.0000000000001139.

DOI:10.1097/DCR.0000000000001139
PMID:29994956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6044457/
Abstract

A 63-year-old man presents to his primary care doctor with a one-month history of blood in his stools. He is referred for a colonoscopy and found to have a friable mass along the anterior wall just proximal to the second rectal fold. A biopsy confirms moderately-differentiated adenocarcinoma. The patient then obtains pelvic magnetic resonance imaging and chest, abdomen, and pelvis computed tomography demonstrating local invasion of the primary tumor into the mesorectal fat (T3), no suspicious regional lymph nodes (N0), and no evidence of distant metastatic disease (M0).

摘要

一位 63 岁男性因一个月来大便带血到其初级保健医生处就诊。他被转介进行结肠镜检查,发现前壁靠近第二直肠折处有一个易碎的肿块。活检证实为中分化腺癌。随后,患者进行了盆腔磁共振成像和胸部、腹部及盆腔计算机断层扫描,显示原发肿瘤局部侵犯中直肠脂肪(T3),无可疑区域淋巴结(N0),也无远处转移疾病的证据(M0)。

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本文引用的文献

1
Effect of Interval (7 or 11 weeks) Between Neoadjuvant Radiochemotherapy and Surgery on Complete Pathologic Response in Rectal Cancer: A Multicenter, Randomized, Controlled Trial (GRECCAR-6).新辅助放化疗与手术间隔(7 或 11 周)对直肠癌完全病理缓解的影响:一项多中心、随机、对照试验(GRECCAR-6)。
J Clin Oncol. 2016 Nov 1;34(31):3773-3780. doi: 10.1200/JCO.2016.67.6049.
2
Practice parameters for the management of rectal cancer (revised).直肠癌管理的实践参数(修订版)
Dis Colon Rectum. 2013 May;56(5):535-50. doi: 10.1097/DCR.0b013e31828cb66c.
3
Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04.T3 期直肠癌患者短程放疗与长程放化疗局部复发率比较的随机试验:跨塔斯曼肿瘤放疗组试验 01.04.
J Clin Oncol. 2012 Nov 1;30(31):3827-33. doi: 10.1200/JCO.2012.42.9597. Epub 2012 Sep 24.
4
MR volumetric measurement of low rectal cancer helps predict tumor response and outcome after combined chemotherapy and radiation therapy.磁共振容积测量低位直肠癌有助于预测联合化疗和放疗后的肿瘤反应和结果。
Radiology. 2012 May;263(2):409-18. doi: 10.1148/radiol.12111263. Epub 2012 Mar 21.
5
Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study.术前高分辨率磁共振成像可识别最佳单独手术治疗的预后良好的 I、II 和 III 期直肠癌:一项前瞻性、多中心、欧洲研究。
Ann Surg. 2011 Apr;253(4):711-9. doi: 10.1097/SLA.0b013e31820b8d52.
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Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer.斯德哥尔摩 III 期试验中直肠癌术前放疗方案的中期分析。
Br J Surg. 2010 Apr;97(4):580-7. doi: 10.1002/bjs.6914.
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Techniques and trouble-shooting in high spatial resolution thin slice MRI for rectal cancer.直肠癌高空间分辨率薄层MRI的技术与故障排除
Br J Radiol. 2005 Mar;78(927):245-51. doi: 10.1259/bjr/33540239.
8
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer.术前放疗联合全直肠系膜切除术治疗可切除直肠癌。
N Engl J Med. 2001 Aug 30;345(9):638-46. doi: 10.1056/NEJMoa010580.
9
Improved survival with preoperative radiotherapy in resectable rectal cancer.术前放疗可提高可切除直肠癌患者的生存率。
N Engl J Med. 1997 Apr 3;336(14):980-7. doi: 10.1056/NEJM199704033361402.