Baumann Kerry B, Betz Sasha J
Department of Oral and Maxillofacial Pathology, Naval Post Graduate Dental School, Bethesda, MD, USA.
Department of Oral and Maxillofacial Pathology, Naval Medical Center San Diego, San Diego, CA, USA.
Head Neck Pathol. 2019 Dec;13(4):661-663. doi: 10.1007/s12105-018-0947-x. Epub 2018 Jul 11.
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare entity. Patients often present with complaints of nasal fullness, obstruction, and epistaxis. It may be confused with metastatic papillary thyroid carcinoma due to its histologic similarity and overlapping immunohistochemical studies, but it is important to distinguish between the two because of differing treatment modalities and prognosis. A significant difference between the two is that despite both entities demonstrating TTF-1 positivity, TL-LGNPPA usually does not stain for thyroglobulin. TL-LGNPPA exhibits indolent growth, with no incidence of metastasis or recurrence after surgical excision.
甲状腺样低级别鼻咽乳头状腺癌（TL-LGNPPA）是一种罕见的疾病。患者常主诉有鼻堵塞感、鼻塞和鼻出血。由于其组织学相似性以及免疫组化研究结果重叠，它可能会与转移性甲状腺乳头状癌混淆，但鉴于治疗方式和预后不同，区分两者很重要。两者之间的一个显著差异是，尽管这两种疾病均显示甲状腺转录因子-1（TTF-1）阳性，但TL-LGNPPA通常不表达甲状腺球蛋白。TL-LGNPPA生长缓慢，手术切除后无转移或复发情况。
