甲状腺样低级别鼻咽部乳头状腺癌的免疫组织化学特征：一例报告及文献复习。
Immunohistochemical characteristics of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and review.
机构信息
Graduate school of Hubei University of Medicine, Hubei, China.
Department of Otolaryngology Head and Neck Surgery, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Prefecture, China.
出版信息
Medicine (Baltimore). 2023 Jan 27;102(4):e32655. doi: 10.1097/MD.0000000000032655.
BACKGROUND
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare nasopharyngeal malignant tumor that is easy to misdiagnose. Immunohistochemistry plays an indispensable role in distinguishing TL-LGNPPA from other malignancies. However, there is no article to summarize the immunohistochemical characteristics of TL-LGNPPA. Herein, we report a case of TL-LGNPPA and present the immunohistochemical results reported in the Chinese literature.
METHODS
An electronic search of the CNKI (China National Knowledge Infrastructure) database was performed. From our literature survey, 53 cases of TL-LGNPPA (including the case described in this report) have been identified in China. We summarize the Chinese literature's clinical characteristics, immunohistochemical results, treatments, and prognosis of 53 cases.
RESULTS
Based on our literature survey, 53 cases of TL-LGNPPA (including the case described in this report) have been reported in China. We found TL-LGNPPA and papillary thyroid carcinoma were positive for TTF-1 and CK19. TL-LGNPPA was negative for TG and PAX-8, whereas papillary thyroid carcinoma was positive for TG and PAX-8. However, negative expression of TTF-1 and positive expression of TG were also found in some TL-LGNPPA cases. Our literature survey found that all TL-LGNPPA cases were negative for PAX-8.Therefore, we suggest that simultaneous immunohistochemical determination of TTF-1 and CK19, as well as TG and PAX-8, can increase the diagnostic accuracy of TL-LGNPPA.
CONCLUSION
The 4th edition of the World Health Organization Classification of Head and Neck Tumors (WHO-HNT) indicates that NPPA with positive expression of cytokeratin 19 (CK19) and TTF-1 and negative expression of TG is called TL-LGNPPA.
背景
甲状腺样低级别鼻咽部乳头状腺癌（TL-LGNPPA）是一种罕见的鼻咽部恶性肿瘤，容易误诊。免疫组织化学在鉴别 TL-LGNPPA 与其他恶性肿瘤方面发挥着不可或缺的作用。然而，尚无文章总结 TL-LGNPPA 的免疫组织化学特征。本文报道 1 例 TL-LGNPPA 病例，并呈现中文文献中报道的免疫组化结果。
方法
在中国知网（CNKI）数据库中进行电子检索。通过文献调查，我们在中国发现了 53 例 TL-LGNPPA（包括本报告中描述的病例）。我们总结了 53 例 TL-LGNPPA 的临床特征、免疫组化结果、治疗方法和预后。
结果
根据我们的文献调查，中国共报道了 53 例 TL-LGNPPA（包括本报告中描述的病例）。我们发现 TL-LGNPPA 和甲状腺乳头状癌均表达 TTF-1 和 CK19。TL-LGNPPA 不表达 TG 和 PAX-8，而甲状腺乳头状癌则表达 TG 和 PAX-8。然而，我们的文献调查也发现一些 TL-LGNPPA 病例中存在 TTF-1 阴性和 TG 阳性的表达。我们的文献调查发现所有 TL-LGNPPA 病例均不表达 PAX-8。因此，我们建议同时进行 TTF-1 和 CK19 的免疫组织化学检测，以及 TG 和 PAX-8 的免疫组织化学检测，可以提高 TL-LGNPPA 的诊断准确性。
结论
第 4 版世界卫生组织头颈部肿瘤分类（WHO-HNT）将 CK19 和 TTF-1 阳性、TG 阴性的 NPPA 称为 TL-LGNPPA。
Zotero 插件