Louis J P, Panon G, Le Gonidec G
Med Trop (Mars). 1985 Jul-Sep;45(3):223-33.
After an outbreak in 1956, poliomyelitis appears to get a sporadic development. Consequently, it has not been a major medical concern. In 1982, 5 cases of paralytic manifestations due to a polio virus of type 1 underlined the relationship between this reappearance of the disease, some neglecting in mass vaccination and some deficiency in sanitary conditions of the surroundings. A serologic monitoring, complementary to that survey, has been conducted up to 1984. It has shown that, in a number of zones of the territory, a natural immunization has appeared quickly. This immunization is of the same type that in some underdeveloped tropical countries: at 6, 93,3% of the children present protective antibodies against 1 type of virus, 40% against 2 types and 6,7% against the 3 types. Vaccination with non-active vaccine, adopted because the risks of interference linked to the frequency of excretion of the enteroviruses, is efficient. After a primo-vaccination followed by a booster dose one year later, sero-conversion ranges from 95,3% to 100% for type 1, 83,3% to 96,5% for type 2, 75% to 84,9% for type 3. On the other hand, sero-conversion observed one month after the second vaccination appeared to be unsatisfactory to lighter the vaccinal time-table.
1956年爆发疫情后,脊髓灰质炎呈散发态势发展。因此,它已不再是主要的医学关注点。1982年,5例由1型脊髓灰质炎病毒引起的麻痹性表现凸显了该疾病再次出现与大规模疫苗接种中的一些疏忽以及周边卫生条件的某些缺陷之间的关系。作为该调查的补充,一直进行血清学监测直至1984年。结果显示,在该国的一些地区,迅速出现了自然免疫。这种免疫类型与一些欠发达热带国家相同:6岁儿童中,93.3%的儿童对1型病毒有保护性抗体,40%对2型病毒有保护性抗体,6.7%对3型病毒有保护性抗体。由于肠道病毒排泄频率相关的干扰风险而采用的灭活疫苗接种是有效的。初种疫苗后一年再接种加强剂量,1型病毒的血清转化率为95.3%至100%,2型病毒为83.3%至96.5%,3型病毒为75%至84.9%。另一方面,第二次接种一个月后观察到的血清转化率似乎不尽人意,促使缩短疫苗接种时间表。