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[脊髓灰质炎免疫状况。1993年脊髓灰质炎血清学调查]

[Status of immunity against poliomyelitis. Polio serosurvey in 1993].

作者信息

Diedrich S, Schreier E

机构信息

Nationales Referenzzentrum für Poliomyelitis und Enteroviren, Robert-Koch-Institut, Berlin.

出版信息

Dtsch Med Wochenschr. 1995 Feb 24;120(8):239-44. doi: 10.1055/s-2008-1055339.

Abstract

For the first time immunity against polio was analysed for the populations of both the former "East" and "West" parts of Germany, which had previously been regularly monitored separately. 10 centres for virological diagnosis collaborated. All sera were obtained between May and October 1993, a total of 3266 sera from 8 age groups. The microneutralization test was used to demonstrate antibodies against the three polio virus types. The following antibody frequencies (range in the different age groups) were found: against polio type 1, 91-93%; type 2, 93-95%; type 3, 79-81%. The seroprevalence of antibodies against polio virus types 1 and 2 of over 90% indicates good population immunity. As for virus type 3, the threshold value of 80% was exceeded in some regions. 72-75% of those tested had a neutralising antibody titre of > or = 1:4 against all three polio virus types, while in 1-2% no antibodies were found. Overall conclusion is that the relatively low state of immunity against polio virus 3 should be carefully monitored in some regions.

摘要

首次对德国前“东”部和“西”部的人群进行了脊髓灰质炎免疫分析,此前这两个地区一直分别进行定期监测。10个病毒学诊断中心参与了合作。所有血清均于1993年5月至10月期间采集,共采集了来自8个年龄组的3266份血清。采用微量中和试验检测针对三种脊髓灰质炎病毒型别的抗体。结果发现以下抗体频率(不同年龄组的范围):针对脊髓灰质炎1型,91 - 93%;2型,93 - 95%;3型,79 - 81%。针对脊髓灰质炎1型和2型的抗体血清阳性率超过90%,表明人群免疫状况良好。至于3型病毒,在一些地区超过了80%的阈值。72 - 75%的受测者针对所有三种脊髓灰质炎病毒型别的中和抗体滴度≥1:4,而1 - 2%的受测者未检测到抗体。总体结论是,在一些地区应密切监测针对脊髓灰质炎3型病毒相对较低的免疫状态。

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