Fofana Y, Ehrengut W, Koch I, Allerdist H, Diallo D
Med Trop (Mars). 1981 Mar-Apr;41(2):151-5.
In tropical areas transport and storage of living antipoliomyelitic vaccine are difficult and consequently it is considered as hazardous to get a correct immunity with this vaccine. Still, good results have been obtained in Mali children with Sabin vaccine. A previous virological survey has shown that 31 p. 100 of children below 3 years carry enterovirus which are, for 30 p. 100 of them, wild poliovirus. In a serological survey conducted during the same period, near 50 p. 100 of the children in that age group were seronegative for the 3 types of virus and 90 p. 100 of the children between 4 to 7 had neutralizing antibodies against type I, 88 p. 100 against type II and 67 p. 100 against type III. By doubling or trebling the immunizing dose at the first vaccination, the following results have been observed after the second vaccination: 86 p. 100 of the immunized children under 3 years had neutralizing antipoliomyelitic antibodies (titre 1/10) against type I and II and 64 p. 100 against type III, whereas, in the elder group (from 4 to 7) the conversion rate is 100 p. 100 for types I and II and 96 p. 100 for type III.
在热带地区，脊髓灰质炎活疫苗的运输和储存存在困难，因此人们认为使用这种疫苗获得正确的免疫力存在风险。尽管如此，在马里儿童中使用萨宾疫苗仍取得了良好效果。此前的一项病毒学调查显示，3岁以下儿童中有31%携带肠道病毒，其中30%携带野生脊髓灰质炎病毒。在同一时期进行的一项血清学调查中，该年龄组近50%的儿童对三种病毒血清学检测呈阴性，4至7岁儿童中90%对I型病毒有中和抗体，88%对II型病毒有中和抗体，67%对III型病毒有中和抗体。在首次接种时将免疫剂量加倍或增至三倍，第二次接种后观察到以下结果：3岁以下免疫儿童中，86%对I型和II型病毒有中和性抗脊髓灰质炎抗体（滴度1/10），64%对III型病毒有中和性抗脊髓灰质炎抗体；而在年龄较大的组（4至7岁）中，I型和II型病毒的转化率为100%，III型病毒的转化率为96%。
