Lauffer L, Garcia P D, Harkins R N, Coussens L, Ullrich A, Walter P
Nature. 1985;318(6044):334-8. doi: 10.1038/318334a0.
The signal recognition particle (SRP) receptor is an integral membrane protein of the endoplasmic reticulum which, in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to this membrane system. From the complementary DNA sequence we have deduced the complete primary structure of the SRP receptor and established that its amino-terminal region is anchored in the membrane. The anchor fragment and the cytoplasmic fragment contribute jointly to a functionally important region which is highly charged and may function in nucleic acid binding.
信号识别颗粒（SRP）受体是内质网的一种整合膜蛋白，它与SRP一起确保新生分泌蛋白正确靶向到该膜系统。从互补DNA序列中，我们推导了SRP受体的完整一级结构，并确定其氨基末端区域锚定在膜中。锚定片段和细胞质片段共同构成一个功能上重要的区域，该区域带电量很高，可能在核酸结合中发挥作用。
