Horváth A, Slugen I, Ferák I, Hruskovic I, Plesko I, Ondrias F
Neoplasma. 1985;32(5):629-37.
In 70 patients with hepatocellular carcinoma without history of antineoplastic chemotherapeutic drugs, anabolic and contraceptive steroids, representative sections of nonneoplastic liver tissue were examined for the presence of etiological markers. Hepatitis B surface antigen-positive hepatocytes were found in 16 (22.8%), alpha-1-antitrypsin globules in 3 (4.2%), Mallory bodies in 9 (12.8%), acicular inclusions in 1 (1.4%), diffuse giant mitochondria in 2 (2.8%), copper-binding protein in 25 (35.7%), greater amount of hemosiderin in 9 (12.8%) cases. Thorotrast was not detected. One or more markers were seen in 38 (54.3%) cases, most frequently in association with liver cell dysplasia and alcoholism. The presence of hepatitis B surface antigen in livers with dysplastic foci was highly significant as compared to organs showing no dysplasia. Only the mentioned antigen and the alpha-1-antitrypsin globules were found to indicate the etiology of the underlying liver lesion. The value of the other markers was found inconsistent in etiological diagnosis.
在70例无抗肿瘤化疗药物、同化激素及避孕药使用史的肝细胞癌患者中，对非肿瘤性肝组织的代表性切片进行了病因学标志物检查。发现16例（22.8%）有乙肝表面抗原阳性肝细胞，3例（4.2%）有α1抗胰蛋白酶小球，9例（12.8%）有马洛里小体，1例（1.4%）有针状包涵体，2例（2.8%）有弥漫性巨大线粒体，25例（35.7%）有铜结合蛋白，9例（12.8%）有较多含铁血黄素。未检测到钍造影剂。38例（54.3%）病例中可见一种或多种标志物，最常见于与肝细胞发育异常和酒精中毒相关的情况。与无发育异常的肝脏相比，发育异常灶肝脏中乙肝表面抗原的存在具有高度显著性。仅上述抗原和α1抗胰蛋白酶小球被发现可提示潜在肝脏病变的病因。发现其他标志物在病因诊断中的价值不一致。
