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卵巢原发性类癌的临床病理分析

[Clinicopathologic analysis of primary carcinoid of the ovary].

作者信息

Ge H J, Bi R, Cheng Y F, Chang B, Yu L, Tang S X, Shen X X, Yang W T, Tu X Y

机构信息

Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology; Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2018 Jul 8;47(7):517-521. doi: 10.3760/cma.j.issn.0529-5807.2018.07.007.

DOI:10.3760/cma.j.issn.0529-5807.2018.07.007
PMID:29996316
Abstract

To describe the clinicopathologic features, diagnosis and differential diagnosis of ovarian carcinoid tumors. A retrospective chart review was performed of all patients diagnosed with primary ovarian carcinoid tumors at Fudan University Shanghai Cancer Centre from 2007 to 2017. The histologic analysis of these carcinoid tumors revealed 3 were insular, 1 was trabecular, 1 was mucinous, and 10 were strumal. Histologic features of insular and trabecular carcinoid were similar to other parts of the neuroendocrine tumor. Strumal carcinoid was composed of thyroid tissue intimately admixed with carcinoid tumor, showing trabecular pattern. Mucinous carcinoid was resembles Krukenberg tumor. Most ovarian carcinoid tomours were diffusely positive with at least one neuroendocrine marker, especially synaptophysin (14/14) and CD56(9/10). The median follow-up time was 53 months, 1 patient with squamous-cell carcinoma of cervixrecur rence in vaginal after 37 months, and only 1 patient died of disease. The remaining patients were disease-free survival. Primary carcinoid of the ovary is a very rare low grade malignant monodermal teratomas and somatic-type tumours arising from a dermoid. The diagnosis and differential diagnosis mainly relies on the histopathologic characteristics and the immuno-phenotype. Primary ovarian carcinoid almost always exhibit a benign clinical behavious except mucinous carcinoid.

摘要

描述卵巢类癌肿瘤的临床病理特征、诊断及鉴别诊断。对2007年至2017年在复旦大学附属肿瘤医院诊断为原发性卵巢类癌肿瘤的所有患者进行回顾性病历审查。这些类癌肿瘤的组织学分析显示,3例为岛状,1例为小梁状,1例为黏液性,10例为甲状腺肿型。岛状和小梁状类癌的组织学特征与神经内分泌肿瘤的其他部位相似。甲状腺肿型类癌由与类癌肿瘤紧密混合的甲状腺组织组成,呈小梁状模式。黏液性类癌类似于库肯勃瘤。大多数卵巢类癌肿瘤至少对一种神经内分泌标志物呈弥漫性阳性,尤其是突触素(14/14)和CD56(9/10)。中位随访时间为53个月,1例宫颈癌患者在37个月后阴道复发,仅1例患者死于疾病。其余患者无病生存。原发性卵巢类癌是一种非常罕见的低级别恶性单胚层畸胎瘤和源自皮样囊肿的体细胞型肿瘤。诊断及鉴别诊断主要依靠组织病理学特征及免疫表型。除黏液性类癌外,原发性卵巢类癌几乎总是表现出良性的临床行为。

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