Matías-Guiu X, Forteza J, Prat J
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
Int J Gynecol Pathol. 1995 Apr;14(2):179-83. doi: 10.1097/00004347-199504000-00013.
The first example of mixed strumal and mucinous carcinoid tumor of the ovary is reported. The vast majority of the tumor was composed of carcinoid cells arranged in a trabecular-insular configuration admixed with obvious thyroid follicles. In addition, glands lined by mucin-producing cells were seen in some areas. A transition from the strumal carcinoid component to the mucinous glands was seen. Immunohistochemical studies showed that the strumal and mucinous carcinoid components were positive for chromogranin A, serotonin, and vasoactive intestinal polypeptide, clearly demonstrating that both were neuroendocrine in nature.
本文报道了卵巢混合性甲状腺肿样和黏液性类癌肿瘤的首例病例。肿瘤的绝大部分由呈小梁状-岛状排列的类癌细胞组成，并混有明显的甲状腺滤泡。此外，在某些区域可见由黏液分泌细胞衬覆的腺体。可见从甲状腺肿样类癌成分向黏液性腺体的过渡。免疫组化研究显示，甲状腺肿样和黏液性类癌成分嗜铬粒蛋白A、5-羟色胺和血管活性肠多肽均呈阳性，清楚地表明二者本质上均为神经内分泌性肿瘤。
