Shi Xu-Liu, Yan Jian-Kun, Li Wen-Kai, Donkor Paul Owusu, Gao Xiu-Mei, Ding Li-Qin, Qiu Feng
a School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin 300110 , China.
b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300110 , China.
J Asian Nat Prod Res. 2018 Nov;20(11):1045-1054. doi: 10.1080/10286020.2018.1483347. Epub 2018 Jul 12.
Two pairs of phenylpropanoid enantiomers, (+)-(7S,8S)-alatusol D (1a), (-)-(7R,8R)-alatusol D (1b), (-)-(7S,8R)-alatusol D (2a) and (+)-(7R,8S)-alatusol D (2b) were isolated from the leaves of Eucommia ulmoides Oliver. Among them, 1a and 2b were firstly obtained by chiral enantiomeric resolution. Their structures were elucidated based on extensive spectroscopic analysis and the induced CD (ICD) spectrum caused by adding Mo(AcO) in DMSO. All compounds were tested on Hep G2 tumor cell lines. However, none of the compounds showed potential cytotoxic activity against Hep G2 in vitro.
从杜仲（Eucommia ulmoides Oliver）叶中分离出两对苯丙素对映体，即(+)-(7S,8S)-翅果醇D（1a）、(-)-(7R,8R)-翅果醇D（1b）、(-)-(7S,8R)-翅果醇D（2a）和(+)-(7R,8S)-翅果醇D（2b）。其中，1a和2b首次通过手性对映体拆分获得。基于广泛的光谱分析以及在二甲基亚砜（DMSO）中加入乙酸钼（Mo(AcO)）所引起的诱导圆二色（ICD）光谱对其结构进行了阐明。所有化合物均在肝癌细胞系Hep G2上进行了测试。然而，这些化合物在体外对Hep G2均未显示出潜在的细胞毒性活性。
