CD34、Ki67、浸润层与胃肠道间质瘤临床病理特征及预后结局的相关性——一项回顾性队列研究

Associations of CD34, Ki67, layer of invasion and clinical pathological characteristics, prognosis outcomes in gastrointestinal stromal tumors-a retrospective cohort study.

作者信息

Yang Jianqi, Xing Enming, Zhang Xian, Cao Wenmiao, Liang Yichen

机构信息

Clinical Medical College, Yangzhou University, Yangzhou, China.

Department of Oncology, Northern Jiangsu People's Hospital, Yangzhou, China.

出版信息

Transl Cancer Res. 2022 Aug;11(8):2866-2875. doi: 10.21037/tcr-22-1777.

DOI:10.21037/tcr-22-1777

PMID:36093530

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9459586/

Abstract

BACKGROUND

Gastrointestinal stromal tumors (GIST) is the most common interstitial tumor of the digestive tract. GIST, like other malignancies, can recur, metastasize, and even metastasize to the brain, leading to death. Therefore, the prevention and treatment of GIST is very important. The clinical features of GIST are uniquely different to those of other common malignancies. Therefore, it is of great significance to explore the relationship between the pathological features and prognosis of GIST to strengthen the prevention and treatment of GIST. The objectives of this study were to study the clinical features of Ki67, Cluster Differentiation 34 (CD34), and their correlations in the Jianghuai region of China in recent years, and to analyze their relationship with prognosis.

METHODS

A total of 423 cases of GIST in Northern Jiangsu People's Hospital in Yangzhou from 2013 to 2020 were retrospectively analyzed. The data of CD34, Ki67 and layer of invasion was collected, and their associations with the clinical pathological characteristics, prognosis outcomes of GIST were studied. CD34 and Ki67 were tested by immunohistochemistry (IHC) And data was analyzed by chi-square test, -test, Kaplan-Meier (KM) method survival curve, Log-rank test, and Cox regression.

RESULTS

The results showed that CD34 was associated with the clinical features of primary site, tumor size, risk, recurrence, and progression-free survival (PFS) (P<0.001, =0.01, <0.001, =0.039 and =0.018), but not with nuclear division or overall survival (OS) (P>0.05). Further, Ki67 was associated with nuclear division, tumor size, risk, recurrence, and PFS (P<0.001, <0.001, <0.001, <0.001 and <0.001), but there was no significant correlation with the primary site and CD34 (P>0.05), and Ki67 was associated with OS, but there was no statistical significance (P=0.0507). The layer of invasion was associated with the primary site, nuclear division, tumor size, risk, CD34, smooth muscle actin (SMA), recurrence, Ki67, and PFS (P<0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001 and =0.0025), but not with OS (P=0.6680).

CONCLUSIONS

CD34, Ki67, and layer of invasion may play important roles in the occurrence and development of GIST, affecting the prognosis of GIST.

摘要

背景

胃肠道间质瘤（GIST）是消化道最常见的间叶源性肿瘤。GIST与其他恶性肿瘤一样，会复发、转移，甚至转移至脑部，导致死亡。因此，GIST的防治非常重要。GIST的临床特征与其他常见恶性肿瘤有独特的差异。因此，探讨GIST的病理特征与预后的关系，对于加强GIST的防治具有重要意义。本研究的目的是研究近年来中国江淮地区Ki67、分化簇34（CD34）的临床特征及其相关性，并分析它们与预后的关系。

方法

回顾性分析2013年至2020年扬州市苏北人民医院423例GIST病例。收集CD34、Ki67和浸润层的数据，研究它们与GIST临床病理特征、预后结果的相关性。采用免疫组织化学（IHC）检测CD34和Ki67，并通过卡方检验、t检验、Kaplan-Meier（KM）法生存曲线、Log-rank检验和Cox回归分析数据。

结果

结果显示，CD34与原发部位、肿瘤大小、风险、复发和无进展生存期（PFS）的临床特征相关（P<0.001、P=0.01、P<0.001、P=0.039和P=0.018），但与核分裂或总生存期（OS）无关（P>0.05）。此外，Ki67与核分裂、肿瘤大小、风险、复发和PFS相关（P<0.001、P<0.001、P<0.001、P<0.001和P<0.001），但与原发部位和CD34无显著相关性（P>0.05），Ki67与OS相关，但无统计学意义（P=0.0507）。浸润层与原发部位、核分裂、肿瘤大小、风险、CD34、平滑肌肌动蛋白（SMA）、复发、Ki67和PFS相关（P<0.001、P<0.001、P<0.001、P<0.001、P<0.001、P<0.001、P<0.001、P<0.001和P=0.0025），但与OS无关（P=0.6680）。