Iba Ba J, Andjuma Mindze P L, Nseng Nseng I, Nzenze J R, Boguikouma J B
CHU de Libreville, BP2228 Libreville, Gabon.
Service de rhumatologie, CHU de Cocody, Abidjan, Cote d'Ivoire.
Med Sante Trop. 2018 May 1;28(2):165-171. doi: 10.1684/mst.2018.0798.
Lupus is an autoimmune disease of the connective tissue that occurs predominantly in women and blacks and whose expression is influenced by environmental factors, especially ultraviolet rays. The rising temperature in Gabon for nearly two decades led us to look for correlations between the onset of lupus, the patients' regions of origin, and environmental temperatures before and at diagnosis. retrospective, descriptive, and analytic study conducted in the Department of Internal Medicine of the CHU of Libreville (Gabon), from 01/01/2016 to 31/05/2016, based on the files of patients with diagnosed lupus receiving care in the department since 01/2002. Data collection forms listed for each patients age, sex, occupation, date and season of diagnosis, and place of residence (during childhood, adolescence, and adulthood). We looked for correlations between these data and temperatures, based on meteorological data from the country's seven main weather stations over a period from 1996 to 2015. The study included 53 women and 7 men (sex ratio 0.13), with a mean age of 32.7 +/- 8.9 years. The population included students (n = 25), civil servants (n = 15), the unemployed (n = 8), private-sector employees (n = 6), and shopkeepers (n=6). Diagnoses varied according to season, with 56.6% of the cases in the dry season and 43.4% in the rainy season. From 1 to 4 cases of lupus were diagnosed annually before 2011, 7 each year from 2011 to 2014, and at least 14 per year since 2015. Most patients (62.5%) had spent their childhood, adolescence, and adulthood in the country's capital (industrial zone par excellence), 17.8% in mining regions, and 12.5% in oil-drilling areas. The increase in the number of cases of lupus appears to be correlated with their greater prevalence in regions with higher temperature exposures, that is, in industrial, mining and petroleum regions, which are the regions of greatest exposure among our lupus patients.
狼疮是一种结缔组织自身免疫性疾病，主要发生在女性和黑人中，其病情表现受环境因素影响，尤其是紫外线。加蓬近二十年来气温不断上升，这促使我们去探寻狼疮的发病、患者的原籍地区以及诊断前和诊断时的环境温度之间的关联。在利伯维尔（加蓬）大学医院内科开展了一项回顾性、描述性和分析性研究，研究时间为2016年1月1日至2016年5月31日，基于自2002年1月以来在该科室接受治疗的已确诊狼疮患者的病历。数据收集表列出了每位患者的年龄、性别、职业、诊断日期和季节以及居住地（童年、青少年和成年时期）。我们根据该国七个主要气象站1996年至2015年期间的气象数据，探寻这些数据与温度之间的关联。该研究纳入了53名女性和7名男性（性别比为0.13），平均年龄为32.7±8.9岁。研究对象包括学生（n = 25）、公务员（n = 15）、失业者（n = 8）、私营企业员工（n = 6）和店主（n = 6）。诊断情况因季节而异，56.6%的病例发生在旱季，43.4%发生在雨季。2011年之前每年诊断出1至4例狼疮病例，2011年至2014年每年7例，自2015年起每年至少14例。大多数患者（62.5%）在该国首都（典型的工业区）度过了童年、青少年和成年时期，17.8%在矿区，12.5%在石油钻探地区。狼疮病例数量的增加似乎与温度较高地区（即工业、采矿和石油地区，这些是我们狼疮患者中暴露程度最高的地区）的更高患病率相关。
