Zomalheto Zavier, Assogba Michee, Agbodande Anthelme, Atadokpede Felix, Gounongbe Marcelle, Avimadje Martin
Tunis Med. 2014 Dec;92(12):707-10.
To describe the clinical features, laboratory characteristics and the treatment of systemic lupus erythematosus (SLE) among Benin people and West Africa people.
This is a part of a retrospective study which initially concerned patients seen in the rheumatology, dermatology and internal medicine departments of National Hospital University of Cotonou during January 2000 to March 2013 (14 years). Patients included in the study were all older than 16 years and fulfilling at least four of ACR criteria 1997 for Systemic lupus erythematosus. In a second step, we collect the data of the countries of West Africa where the work on the systemic lupus erythematosus have been published through a literature review including all articles published in the local, regional and international journals. Demographic, clinical and outcomes data were analyzed.
33 cases of lupus were diagnosed in 14 years in Cotonou. The sex ratio was 32/1 and means age 28.76 ± 8.01 [16-51]. The mean delay before diagnosis was 15 months [1- 84 months]. Polyarthralgia/ polyarthritis were the most common presentations (94.3 %) followed by systemic manifestations (78.9 %). Nineteen (19) patients achieved serological profiles. The anti- ds DNA were positive in 15 cases, anti- Sm in 10 cases and anti -SSA in 5 cases. Anti - phospholipids and lupus anticoagulant were absent. Treatment modalities were: corticosteroids (n = 21) antimalarials (n=15) , methotrexate (n = 4) , body corticosteroids (n=5), clinical monitoring without treatment (n = 3). Outcome was satisfactory in 25 cases. Eight (8) patients developed complications, 4 cases of death were observed and 8 patients lost to follow. These data are congruent with those published in the countries of West Africa.
SLE seems rare in Benin. In general, in West Africa, the diagnosis is difficult because the clinical polymorphism by misdiagnosis and access serological profiles difficulty. However, the disease appears to be well controlled by treatment dominated by corticosteroids.
描述贝宁人和西非人群中系统性红斑狼疮（SLE）的临床特征、实验室特点及治疗情况。
这是一项回顾性研究的一部分，该研究最初涉及2000年1月至2013年3月（14年）期间在科托努国立大学医院风湿科、皮肤科和内科就诊的患者。纳入研究的患者均年龄超过16岁，且至少符合1997年美国风湿病学会（ACR）系统性红斑狼疮标准中的四条。第二步，我们通过文献综述收集西非各国系统性红斑狼疮相关研究数据，包括当地、地区和国际期刊上发表的所有文章。对人口统计学、临床和结局数据进行分析。
14年间在科托努诊断出33例狼疮患者。男女比例为32∶1，平均年龄28.76±8.01岁[16 - 51岁]。诊断前平均延迟时间为15个月[1 - 84个月]。多关节痛/多关节炎是最常见的表现（94.3%），其次是全身表现（78.9%）。19例患者获得了血清学检查结果。抗双链DNA阳性15例，抗Sm阳性10例，抗SSA阳性5例。抗磷脂抗体和狼疮抗凝物均为阴性。治疗方式有：皮质类固醇（n = 21）、抗疟药（n = 15）、甲氨蝶呤（n = 4）、局部皮质类固醇（n = 5）、未治疗仅临床监测（n = 3）。25例患者结局良好。8例患者出现并发症，观察到4例死亡，8例患者失访。这些数据与西非各国发表的数据一致。
SLE在贝宁似乎较为罕见。总体而言，在西非，由于临床多态性导致误诊以及血清学检查结果获取困难，诊断较为困难。然而，该疾病似乎通过以皮质类固醇为主的治疗得到了较好控制。
