成纤维样和巨噬样滑膜细胞的本体论与功能：它们如何相互交流以及能否成为类风湿关节炎治疗的靶点？

Tu Jiajie, Hong Wenming, Zhang Pengying, Wang Xinming, Körner Heinrich, Wei Wei

Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.

First Affiliated Hospital of Anhui Medical University, Hefei, China.

Front Immunol. 2018 Jun 26;9:1467. doi: 10.3389/fimmu.2018.01467. eCollection 2018.

Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA). Although various studies have analyzed both human and animal tissues and have shown that both cell types are involved in different stages of RA, ontology, and specific functions of both cell populations and their interactions are not well understood. In this review, we will summarize recent research on FLS and MLS in RA and focus on the development and function of two predominant synovial cell types. In addition, we will discuss the communication between FLS or MLS and highlight potential treatments for RA that involve synoviocytes.

成纤维样滑膜细胞（FLS）和巨噬样滑膜细胞（MLS）是滑膜的两种主要细胞成分。已有广泛报道称，FLS和MLS在类风湿关节炎（RA）的关节病理中起重要作用。尽管各种研究分析了人类和动物组织，并表明这两种细胞类型都参与了RA的不同阶段，但这两种细胞群体的本体论、特定功能及其相互作用尚未得到充分了解。在本综述中，我们将总结RA中FLS和MLS的最新研究，并重点关注两种主要滑膜细胞类型的发育和功能。此外，我们将讨论FLS或MLS之间的通讯，并强调涉及滑膜细胞的RA潜在治疗方法。