Derosa Joseph, van der Puyl Vincent A, Tran Van T, Liu Mingyu, Engle Keary M
Department of Chemistry , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , USA . Email:
Chem Sci. 2018 May 16;9(23):5278-5283. doi: 10.1039/c8sc01735b. eCollection 2018 Jun 21.
A nickel-catalyzed conjunctive cross-coupling of non-conjugated alkenes, alkyl halides, and alkylzinc reagents is reported. Regioselectivity is controlled by chelation of a removable bidentate 8-aminoquinoline directing group. Under optimized conditions, a wide range of 1,2-dialkylated products can be accessed in moderate to excellent yields. To the best of our knowledge, this report represents the first example of three-component 1,2-dialkylation of non-conjugated alkenes to introduce differentiated alkyl fragments.
报道了一种镍催化的非共轭烯烃、卤代烃和烷基锌试剂的联合交叉偶联反应。区域选择性由可移除的双齿8-氨基喹啉导向基团的螯合作用控制。在优化条件下，可以以中等至优异的产率获得多种1,2-二烷基化产物。据我们所知，本报告代表了非共轭烯烃的三组分1,2-二烷基化以引入不同烷基片段的首个实例。
