镍催化烯烃的还原双官能团化反应。
Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes.
机构信息
Department of Chemistry, University of Zurich , Winterthurerstrasse 190, Zurich CH 8057, Switzerland.
出版信息
J Am Chem Soc. 2017 May 24;139(20):6835-6838. doi: 10.1021/jacs.7b03195. Epub 2017 May 10.
PMID:28489351
Abstract
An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp-Csp and Csp-Csp bonds across a variety of π-systems using two different electrophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.
摘要
这里介绍了一种烯烃的分子间、三组分还原双官能化反应。Ni 催化与 TDAE 作为最终还原剂的结合，使得在温和的反应条件下，通过两种不同的、具有精挑细选的选择性依次被激活的亲电试剂，能够在各种π-体系中直接形成 Csp-Csp 和 Csp-Csp 键。
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