Programa de Mestrado em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88302202 Itajaí, SC, Brazil.
Evid Based Complement Alternat Med. 2011;2011:312320. doi: 10.1155/2011/312320. Epub 2011 Jun 30.
There are few studies on the pharmacological properties of Valeriana prionophylla Standl. (VP), known as "Valeriana del monte", and used in Mesoamerican folk medicine to treat sleep disorders. This study examines the pharmacological effects of the hydroalcoholic extract of the dry rhizome using the open field, rota rod, elevated plus-maze (EPM), forced swimming (FST), strychnine- and pentobarbital-induced sleeping time, PTZ-induced seizures, and the inhibitory avoidance tests. VP did not show any protective effect against PTZ-induced convulsions. In the EPM, exhibited an anxiolytic-like effect through the effective enhancement of the entries (38.5%) and time spent (44.7%) in the open arms, when compared with control group. Time spent and the numbers of entrances into the enclosed arms were decreased, similar to those effects observed with diazepam. In the FST, acute treatment with VP, produced a dose-dependent decrease in immobility time, similarly to imipramine. VP also produced a significant dose-dependent decrease in the latency of sleeping time, while producing an increase in total duration of sleep; influenced memory consolidation of the animals only at lower doses, unlike those that produced anti-depressant and anxiolytic effects. In summary, the results suggest that VP presents several psychopharmacological activities, including anxiolytic, antidepressant, and hypno-sedative effects.
关于 Valeriana prionophylla Standl.（俗称“Valeriana del monte”）的药理学特性的研究很少，这种植物被中美洲民间医学用于治疗睡眠障碍。本研究使用开阔场地、旋转棒、高架十字迷宫（EPM）、强迫游泳（FST）、士的宁和戊巴比妥诱导的睡眠时间、PTZ 诱导的癫痫发作和抑制性回避测试来检查干根茎的水醇提取物的药理学作用。VP 对 PTZ 诱导的惊厥没有任何保护作用。在 EPM 中，与对照组相比，VP 通过有效增加进入开放臂的次数（38.5%）和时间（44.7%）表现出类似的抗焦虑作用。进入封闭臂的时间和次数减少，类似于地西泮的作用。在 FST 中，VP 急性治疗可剂量依赖性地减少不动时间，类似于丙咪嗪。VP 还可显著剂量依赖性地降低睡眠时间，同时增加总睡眠时间；与产生抗抑郁和抗焦虑作用的药物不同，它仅在较低剂量下影响动物的记忆巩固。总之，结果表明 VP 具有多种精神药理学作用，包括抗焦虑、抗抑郁和催眠作用。
