Yu Ashley M, Ito Shinya, Leibson Tom, Lavi Sasson, Fu Lisa W, Weinstein Miriam, Skotnicki Sandra M
Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada.
Pediatr Dermatol. 2018 Sep;35(5):e262-e264. doi: 10.1111/pde.13532. Epub 2018 Jul 12.
A 4-year-old boy presented with erythematous vesicular plaques, ulceration, edema, and pruritus on the left foot and ankle 10 days after receiving the tetanus, diphtheria, pertussis, and polio; measles, mumps, rubella, and varicella; and hepatitis A/B vaccines. Biopsy showed eosinophilic infiltrates and flame figures, suggesting Wells syndrome. Patch testing showed a 1+ reaction to neomycin and aluminum hydroxide, with a recall reaction of Wells syndrome of the feet bilaterally. We report a rare case of pediatric Wells syndrome triggered by nonthimerosal vaccine components confirmed by patch testing.
一名4岁男孩在接种破伤风、白喉、百日咳和脊髓灰质炎疫苗；麻疹、腮腺炎、风疹和水痘疫苗；以及甲型/乙型肝炎疫苗10天后，左脚和脚踝出现红斑性水疱斑块、溃疡、水肿和瘙痒。活检显示嗜酸性粒细胞浸润和火焰状图形，提示为威尔斯综合征。斑贴试验显示对新霉素和氢氧化铝有1+反应，双侧足部出现威尔斯综合征的回忆反应。我们报告了一例罕见的由非硫柳汞疫苗成分引发的儿童威尔斯综合征病例，该病例经斑贴试验确诊。
